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A global research community of scientists is teasing out the biochemical mechanisms that regulate normal cellular physiology in a variety of organisms. Much of current research aims to understand the network of molecular reactions that regulate cellular homeostasis, and to learn what allows cells to sense stress and activate appropriate biochemical responses. Advanced molecular tools and state-of-the-art imaging techniques discussed in this book continue to provide novel insights into how environmental changes impact organisms, as well as to develop therapeutic interventions for correcting aberrant pathways in human disease.