This second edition presents the principles and components that underlie signaling processes. Intended for undergraduate and graduate students, the book aims to develop a broad conceptual framework through which students can make sense of the myriad pathways used by the cells to communicate.
This second edition presents the principles and components that underlie signaling processes. Intended for undergraduate and graduate students, the book aims to develop a broad conceptual framework through which students can make sense of the myriad pathways used by the cells to communicate.
Wendell A. Lim is Professor of Cellular and Molecular Pharmacology at the University of California, San Francisco. The principal focus of his research is the structure and mechanism of protein interaction domains and the logic by which these components are used to build complex cellular signaling systems. Bruce J. Mayer is Professor of Genetics and Genome Sciences at the University of Connecticut, School of Medicine. Current work of his group focuses on characterizing and manipulating tyrosine kinase-mediated signal transduction pathways.
Inhaltsangabe
1. Introduction to Cell Signaling. 2. Principles and Mechanisms of Protein Interactions. 3. Signaling Enzymes and Their Allosteric Regulation. 4. Role of Post-Translational Modifications in Signaling. 5. Subcellular Localization of Signaling Molecules. 6. Second Messengers: Small Signaling Mediators. 7. Membranes, Lipids, and Enzymes that Modify Them. 8. Information Transfer Across the Membrane. 9. Regulated Protein Degradation. 10. The Modular Architecture and Evolution of Signaling Proteins. 11. Information Processing by Signaling Devices in Networks. 12. Signaling and Disease. 13. Diversity of Signaling Across Phylogeny 14. How Cells Make Decisions. 15. Methods for Studying Signaling Proteins and Networks.
1. Introduction to Cell Signaling. 2. Principles and Mechanisms of Protein Interactions. 3. Signaling Enzymes and Their Allosteric Regulation. 4. Role of Post-Translational Modifications in Signaling. 5. Subcellular Localization of Signaling Molecules. 6. Second Messengers: Small Signaling Mediators. 7. Membranes, Lipids, and Enzymes that Modify Them. 8. Information Transfer Across the Membrane. 9. Regulated Protein Degradation. 10. The Modular Architecture and Evolution of Signaling Proteins. 11. Information Processing by Signaling Devices in Networks. 12. Signaling and Disease. 13. Diversity of Signaling Across Phylogeny 14. How Cells Make Decisions. 15. Methods for Studying Signaling Proteins and Networks.
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