Cell Signaling Reactions

Single-Molecular Kinetic Analysis
Herausgegeben:Sako, Yasushi; Ueda, Masahiro

• Gebundenes Buch

Produktbeschreibung

This book encompasses the exciting developments and challenges in the field of single-molecule kinetic analysis of cell signaling. This is a fast-moving and rapidly expanding research field. We believe firmly that this field promises to be one of the most significant biological areas of this century. Cell signaling is carried out by complicated reaction network of various species of biological macromolecules and single-molecule analyses have already demonstrated its power to unravel complex reaction dynamics in purified systems.
Most of the works have been published in the filed of single-molecule processes in cells focus on dynamic properties (translational movements of the centre of mass) of biological molecules. This book, however, we intend to contain as many kinetic analyses of cell signalling as possible. Although the single-molecule kinetic analysis of cellular systems is a young field compared with the analysis of single-molecule movements in cells, this type of analysis is important because it directly relates to the molecular functions that control cellular behaviour. Future single-molecule kinetic analysis will be largely directed towards cellular systems. We hope this book is interested in wide readers in molecular and cell biology as well as biophysics and biochemistry.

Produktdetails

• Verlag: Springer / Springer Netherlands
• Artikelnr. des Verlages: 12610228, 978-90-481-9863-4
• Seitenzahl: 330
• Erscheinungstermin: 11. November 2010
• Englisch
• Abmessung: 243mm x 164mm x 30mm
• Gewicht: 654g
• ISBN-13: 9789048198634
• ISBN-10: 9048198631
• Artikelnr.: 30842327

Inhaltsangabe

Preface, Yasushi Sako and Masahiro Ueda; List of contributors; 1 Single-molecule kinetic analysis of receptor protein tyrosine kinases, ichio Hiroshima and Yasushi Sako; 2 Single-molecule kinetic analysis of stochastic signal transduction mediated by G-protein coupled chemoattractant receptor, Yukihiro Miyanaga and Masahiro Ueda; 3 Single-molecule analysis of molecular recognition between signaling proteins RAS and RAF, Kayo Hibino and Yasushi Sako; 4 Single-channel structure-function dynamics: The gating of potassium channels, Shigetoshi Oiki; 5 Immobilizing channel molecules in artificial lipid bilayers for simultaneous electrical and optical single channel recordings, Toru Ide, Minako Hirano, and Takehiro Ichikawa; 6 Single-protein dynamics and the regulation of the plasma-membrane Ca2+ pump, Carey K. Johnson, Mangala R. Liyanage, Kenneth D. Osborn, and Asma Zaidi; 7 Single-molecule analysis of cell-virus binding interactions, Terrence M. Dobrowsky and Denis Wirtz; 8 Visualization of the COPII vesicle formation process reconstituted on a microscope, Kazuhito V. Tabata, Ken Sato, Toru Ide, and Hiroyuki Noji; 9 In vivo single-molecule microscopy using the zebrafish model system, Marcel J. M. Schaaf and Thomas S. Schmidt; 10 Analysis of large-amplitude conformational transition dynamics in proteins at the single-molecule level, Haw Yang; 11 Extracting the underlying unique reaction scheme from a single-molecule time series, Chun Biu Li and Tamiki Komatsuzaki; 12 Statistical analysis of lateral diffusion and reaction kinetics of single molecules on the membrane of living cells, Satomi Matsuoka; 13 Noisy signal transduction in cellular systems, Tatsuo Shibata; Index