A focus on generic components of extra- and intracellular signalling pathways allows the student to gain a thorough understanding of the underlying principles of cell signalling before exploring how the individual components interact to form complex signalling pathways
The ubiquity of key signalling mechanisms is highlighted, enabling students to see how similar mechanisms are conserved and harnessed in many different biological systems
Two colour artworks enliven the text, and enable students to visualise the processes and interactions described more easily
The student is directed to carefully chosen further reading articles, allowing them to readily explore key topics in more detail
Companion web site includes figures from the book available to download to facilitate lecture preparation
New to this edition
New two colour text design, to enhance the educational value of the custom-drawn illustrations
Expanded introductory material, to give all students a firmer platform on which to build their knowledge of the subject
Enhanced coverage of G proteins, cytokines, and kinases to reflect recent advances in our knowledge and understanding of these signalling components
Detailed coverage of nitric oxide signalling, a theme which is now central to cell signalling, but which is often neglected in other texts
Enriched pedagogy includes new Boxes, giving definitions of key terms and expanding on key concepts which are introduced in the text, and end of chapter summaries, both of which make the book even easier to learn from
All artwork available to download from the book's companion web site
Cell Signalling presents a carefully structured introduction to this intricate subject, introducing those conserved features which underlie many different extra-and intracellular signalling systems. Starting with an overview of cell signalling, which highlights its importance in many biological systems, the book goes on to explore the key components of extracellular and intracellular signalling mechanisms, before examining how these components come together to create the signalling pathways, which are so crucial to the survival of all living organisms.
Contents
1 Aspects of Cell Signalling
2 Extracellular Signals - Hormones, Cytokines, Growth Factors
3 Detection of Extracellular Signals: The Role of Receptors
4 Protein Phosphorylation, Kinases and Phosphatases
5 Cyclic Nucleotides, Cyclases and G Proteins
6 Inositol Phosphate Metabolism and Roles of Membrane Lipids
7 Intracellular Calcium: Its Control and Role as an Intracellular Signal
8 Reactive Oxygen Species, Reactive Nitrogen Species and Redox Signalling
9 Insulin and the Signal Transduction Cascades it Invokes
10 Perception of the Environment
11 Life, death, and Apoptosis
12 Cell Signalling: Importance, Complexity and Future
The ubiquity of key signalling mechanisms is highlighted, enabling students to see how similar mechanisms are conserved and harnessed in many different biological systems
Two colour artworks enliven the text, and enable students to visualise the processes and interactions described more easily
The student is directed to carefully chosen further reading articles, allowing them to readily explore key topics in more detail
Companion web site includes figures from the book available to download to facilitate lecture preparation
New to this edition
New two colour text design, to enhance the educational value of the custom-drawn illustrations
Expanded introductory material, to give all students a firmer platform on which to build their knowledge of the subject
Enhanced coverage of G proteins, cytokines, and kinases to reflect recent advances in our knowledge and understanding of these signalling components
Detailed coverage of nitric oxide signalling, a theme which is now central to cell signalling, but which is often neglected in other texts
Enriched pedagogy includes new Boxes, giving definitions of key terms and expanding on key concepts which are introduced in the text, and end of chapter summaries, both of which make the book even easier to learn from
All artwork available to download from the book's companion web site
Cell Signalling presents a carefully structured introduction to this intricate subject, introducing those conserved features which underlie many different extra-and intracellular signalling systems. Starting with an overview of cell signalling, which highlights its importance in many biological systems, the book goes on to explore the key components of extracellular and intracellular signalling mechanisms, before examining how these components come together to create the signalling pathways, which are so crucial to the survival of all living organisms.
Contents
1 Aspects of Cell Signalling
2 Extracellular Signals - Hormones, Cytokines, Growth Factors
3 Detection of Extracellular Signals: The Role of Receptors
4 Protein Phosphorylation, Kinases and Phosphatases
5 Cyclic Nucleotides, Cyclases and G Proteins
6 Inositol Phosphate Metabolism and Roles of Membrane Lipids
7 Intracellular Calcium: Its Control and Role as an Intracellular Signal
8 Reactive Oxygen Species, Reactive Nitrogen Species and Redox Signalling
9 Insulin and the Signal Transduction Cascades it Invokes
10 Perception of the Environment
11 Life, death, and Apoptosis
12 Cell Signalling: Importance, Complexity and Future