Andere Kunden interessierten sich auch für
![Die zelluläre Differenzierung bedingt die Expression von NDRG1]( "Die zelluläre Differenzierung bedingt die Expression von NDRG1")
Die zelluläre Differenzierung bedingt die Expression von NDRG159,90 €![Warunki ró¿nicowania komórkowego wyra¿enia NDRG1]( "Warunki ró¿nicowania komórkowego wyra¿enia NDRG1")
Warunki ró¿nicowania komórkowego wyra¿enia NDRG139,99 €![Biochemistry of Differentiation and Morphogenesis]( "Biochemistry of Differentiation and Morphogenesis")
Biochemistry of Differentiation and Morphogenesis77,99 €![NRF2 as a Central Point in Cancer Metastasis]( "NRF2 as a Central Point in Cancer Metastasis")
NRF2 as a Central Point in Cancer Metastasis26,99 €![Transcription Factors in Cellular Response to Oxidative Stress]( "Transcription Factors in Cellular Response to Oxidative Stress")
Transcription Factors in Cellular Response to Oxidative Stress36,99 €![PEMT2 Inhibiting Proliferation AND Inducing Apoptosis of Hepatoma Cell]( "PEMT2 Inhibiting Proliferation AND Inducing Apoptosis of Hepatoma Cell")
PEMT2 Inhibiting Proliferation AND Inducing Apoptosis of Hepatoma Cell39,99 €![Can Changes in SR Protein Acetylation Affect Alternative Splicing?]( "Can Changes in SR Protein Acetylation Affect Alternative Splicing?")
Can Changes in SR Protein Acetylation Affect Alternative Splicing?26,99 €
Cellular differentiation is a physiological process that is altered in cancer. N-myc downregulated gene 1 (NDRG1) is a protein which is described as playing a role in cellular differentiation and in suppressing tumor growth. NDRG1 is also known as being induced by cellular stress, including hypoxia. This study provides evidence that NDRG1 is a marker of differentiation. Evidence has been established in two models of cellular differentiation, the well-characterized myelomonocytic cell line U937 and a poorly differentiated cell line, Panc-1, derived from a pancreatic ductal adenocarcinoma. Interestingly, trichostatin A, an epigenetic agent and a histone deacetylase inhibitor, restored the differentiation status of Panc-1 cells and their responsiveness to hypoxia. Furthermore, changes in the transcriptional expression of some genes reported here suggested that the restoration of cellular differentiation may modify the expression profile of other hypoxia-regulated genes toward an improved clinical prognosis. Some drugs of this class have been tested in clinical trials. The book should be especially useful to professionals and students in Cellular and Biomedical Sciences fields.