Céline Tiffon

Cellular differentiation conditions the expression of NDRG1

Hypoxia-inducible expression of N-myc downregulated gene 1 is determined by cellular differentiation

• Broschiertes Buch

Produktbeschreibung

Cellular differentiation is a physiological process that is altered in cancer. N-myc downregulated gene 1 (NDRG1) is a protein which is described as playing a role in cellular differentiation and in suppressing tumor growth. NDRG1 is also known as being induced by cellular stress, including hypoxia. This study provides evidence that NDRG1 is a marker of differentiation. Evidence has been established in two models of cellular differentiation, the well-characterized myelomonocytic cell line U937 and a poorly differentiated cell line, Panc-1, derived from a pancreatic ductal adenocarcinoma. Interestingly, trichostatin A, an epigenetic agent and a histone deacetylase inhibitor, restored the differentiation status of Panc-1 cells and their responsiveness to hypoxia. Furthermore, changes in the transcriptional expression of some genes reported here suggested that the restoration of cellular differentiation may modify the expression profile of other hypoxia-regulated genes toward an improved clinical prognosis. Some drugs of this class have been tested in clinical trials. The book should be especially useful to professionals and students in Cellular and Biomedical Sciences fields.

Produktdetails

• Verlag: Scholar's Press
• Seitenzahl: 116
• Erscheinungstermin: 23. Oktober 2019
• Englisch
• Abmessung: 220mm x 150mm x 7mm
• Gewicht: 191g
• ISBN-13: 9786138915195
• ISBN-10: 6138915194
• Artikelnr.: 57965318

Autorenporträt

Céline Tiffon, M.Sc, M.Res, Ph.D: Studied Biochemistry and Cell Biology and Physiology at the University of Nice Sophia Antipolis, France. Completed her doctorate in Tumor Biology at the University of Bern, Switzerland. Completed her first postdoctoral fellowship at the Division of Cancer Sciences, Southampton General Hospital, United Kingdom.