Cellular Reprogramming in Stirred Suspension Bioreactors - Shafa, Mehdi
51,99 €
inkl. MwSt.
Versandkostenfrei*
Versandfertig in 6-10 Tagen
  • Broschiertes Buch

The clinical application of stem cells depends on the availability of large number of pluripotent cells that are not restricted by ethical, immunological and technical considerations. Induced Pluripotent Stem cells (iPSCs) have been recently achieved by reprogramming of mouse and human somatic cells by expression of defined transcription factors. Reprogramming of differentiated cells through this technology is a valuable tool to find out the mechanisms of pluripotency and also the potential possibility of producing patient-specific pluripotent stem cells. Despite major improvements in the…mehr

Andere Kunden interessierten sich auch für
Produktbeschreibung
The clinical application of stem cells depends on the availability of large number of pluripotent cells that are not restricted by ethical, immunological and technical considerations. Induced Pluripotent Stem cells (iPSCs) have been recently achieved by reprogramming of mouse and human somatic cells by expression of defined transcription factors. Reprogramming of differentiated cells through this technology is a valuable tool to find out the mechanisms of pluripotency and also the potential possibility of producing patient-specific pluripotent stem cells. Despite major improvements in the methods of iPSC generation and expansion, the process still remains inefficient and poorly characterized. This book describes the development of a novel approach for the derivation and expansion of iPSCs. The findings presented in this book show that stirred suspension bioreactors (SSBs) not only suppress differentiation but also provide a novel environment for the expansion and maintenance of iPSCs as well as their efficient derivation.
Autorenporträt
Dr. Mehdi Shafa, born in Iran, is a postdoctoral fellow at the Ottawa hospital research institute (OHRI), where he explores the capacity of embryonic stem cells and induced pluripotent stem cells (iPSCs) to repair lung injury in various animal models. He is the author and co-author of more than 40 scientific publications and book chapters.