Cellular senescence, a multifaceted cellular state - Kobakozete Zezia, Joe
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The aim of this book is to understand the impact that senescent cells can have on the process of remodeling of the extracellular matrix via the secretion of the secretory phenotype associated with senescence but also the consequences of this modification of the extracellular matrix on development. cancers and metastases.Different models of xenografts in vitro and in vivo in mice were used and showed a change in the level of mRNA expression of most factors associated with SASP such as IL-1 , IL-6, IL-8, MMP -1, MMP-3, MMP-10, MMP-12, VEGF etc. in senescent models compared to non-senescent…mehr

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Produktbeschreibung
The aim of this book is to understand the impact that senescent cells can have on the process of remodeling of the extracellular matrix via the secretion of the secretory phenotype associated with senescence but also the consequences of this modification of the extracellular matrix on development. cancers and metastases.Different models of xenografts in vitro and in vivo in mice were used and showed a change in the level of mRNA expression of most factors associated with SASP such as IL-1 , IL-6, IL-8, MMP -1, MMP-3, MMP-10, MMP-12, VEGF etc. in senescent models compared to non-senescent models.These different factors secreted as a result of their overexpression promote excessive degradation of the extracellular matrix and chronic inflammation, the starting point for the occurrence of an epithelial-mesenchymal transition which in turn initiates the development of cancer cells.Thus, the therapeutic approach aimed at eliminating senescent cells using senolytic drugs seems to be effective during aging but also in the fight against age-related diseases associated with it.
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Autorenporträt
Joe KOBAKOZETE ZEZIA: Doctor en Medicina por la Universidad Protestante del Congo (Kinshasa), formación en Máster en Bioquímica, Biología Molecular y Celular en la Universidad de Namur (Bélgica) desde 2018 y en Máster Especializado en Medicina Transfusional en la 'Universidad Católica de Lovaina (Bélgica) desde 2021.