Cellular Senescence and Tumor Suppression

Herausgegeben:Adams, Peter D.; Sedivy, John M.

• Gebundenes Buch

Produktbeschreibung

As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.

Produktdetails

• Verlag: Springer / Springer New York / Springer, Berlin
• Artikelnr. des Verlages: 12111190, 978-1-4419-1074-5
• 2010
• Seitenzahl: 288
• Erscheinungstermin: 17. Dezember 2009
• Englisch
• Abmessung: 241mm x 160mm x 23mm
• Gewicht: 656g
• ISBN-13: 9781441910745
• ISBN-10: 1441910743
• Artikelnr.: 26525586

Inhaltsangabe

Senescence signals.- Telomere Biology and Biochemistry.- Role of RecQ Helicases in Nuclear DNA Repair and Telomere Maintenance.- Oncogene-Induced Senescence (OIS) as a Cellular Response to Oncogenic Stresses.- Stress-Induced Senescence.- The senescent phenotype.- The Secretome of Senescent Cells.- Chromatin Structure in Senescent Cells.- A Comparison of Senescence in Mouse and Human Cells.- The physiological consequences of senescence.- Replicative Senescence as an Intrinsic Tumor-Suppressor Mechanism.- Telomere Dysfunction and Senescence in Stem Cell and Tissues Aging.- Mining Cellular Senescence for Drug Targets.