From the present results and previous studies, it could be concluded that the neurotoxicity which caused by different cement components may be, in part, due to the elevation in glutamate which lead to increase the intracellular of calcium concentration and the inhibition of membrane-bound Na+, K+, Ca2+ ATPase activity which lead to cellular alterations and death. So long term exposure to cement components as environmental pollutants may lead to neurodegenerative diseases.