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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Center surround antagonism refers to antagonistic interactions between center and surround regions of the receptive fields of photoreceptor cells in the retina. Center surround antagonism enables edge detection and contrast enhancement within the visual cortex. In chemistry, antagonism is a phenomenon where two or more agents in combination have an overall effect which is less than the sum of their individual effects.