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Resveratrol is a bioflavone, obtained from grape skin. It exerts variety of biochemical and pharmacological effects. Recently considerable interest has been focused on resveratrol because of its anti oxidant, anti inflammatory and anti proliferative activities. Oxidative stress and inflammation are thought to be key pathological events in ischemic reperfusion injury. ROS overproduction leads to inflammatory cascades which further worsen the ischemic condition by damaging lipids, proteins and nucleic acids. There is an increasing evidence supporting the hypothesis that resveratrol can provide protection against neurodegenerative changes associated with cerebral ischemia and reperfusion injury. The book reviews the neuroprotective effect of resveratrol that have been studied by several authors in animal models of cerebral ischemia and reperfusion.