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Chalcone is chemically 1,3-diaryl-prop-2-en-1-one core. It is a dominant and versatile bio-active template in synthetic organic chemistry. Chalcone reveals numerous biological activities including anticancer and anti-HIV that deal with the promising core for developing effective drugs. It is very easy in synthetic point of view by condensing of aryl aldehyde and aryl ketone. I lore this book assist a graduate, postgraduate students and young researchers.