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Most of the new chemical entity discovered are lipophilic in nature and faces the problem of poor biopharmaceutical properties, among these properties solubility remains a key issue. Improving the aqueous solubility of drug is one of the main challenges to pharmaceutical industry. Various approaches are used for improving solubility of drugs like salt formation, emulsification, co-solvency, use of polymer, micronisation, solid dispersion, inclusion complex etc. Cocrystal synthesis may offer opportunity to pharmaceutical industry to address intellectual property issue by extending the life…mehr

Produktbeschreibung
Most of the new chemical entity discovered are lipophilic in nature and faces the problem of poor biopharmaceutical properties, among these properties solubility remains a key issue. Improving the aqueous solubility of drug is one of the main challenges to pharmaceutical industry. Various approaches are used for improving solubility of drugs like salt formation, emulsification, co-solvency, use of polymer, micronisation, solid dispersion, inclusion complex etc. Cocrystal synthesis may offer opportunity to pharmaceutical industry to address intellectual property issue by extending the life cycle of old APIs. Cocrystallization technique can be a feasible and valuable technique and can be applied to various other clinically important poorly water-soluble phytoconstituents in order to improve their solubility, safety, efficacy and bioavailability as well as clinical applicability.
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Autorenporträt
Frau Sonali R. Devne hat ihren B. Pharm von NDMVP's College of Pharmacy Nashik, Pune University und M. Pharm von Bharati Vidyapeeth Poona Colleg of Pharmacy, Pune abgeschlossen. Sie hat 2,5 Jahre Lehrerfahrung. Derzeit arbeitet sie als Assistenzprofessorin in der Abteilung für Pharmazie, SGMSPM's Dnyanvilas College of Pharmacy, Dudulgaon, PCMC, Indien.