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Millions of people each year spend long weeks in hospital after severe crashes. The WHO estimated that 1.3million people were killed by Road Traffic Crashes (RTC) and 50 million injured on the worlds road annually, adding that over 80 percent of the figure occurred in developing countries, with Africa having the highest death rate. This book investigates the characteristics, causes and spillover effects of RTC and provides an evidence based framework that should enable the orientation of safety and injury prevention policies targeted towards reducing the frequency of RTC and ultimately, lowering the number of deaths that result from RTC. In particular, methodological issues for investigating the dynamics of RTC were examined. The spatial autoregressive with instrumental variable models were found to be more informative and appropriate for modeling road traffic crashes than the spatial autoregressive model.