Charles of Guise, Cardinal of Lorraine, (17 February 1524 26 December 1574), Duke of Chevreuse, was a French Cardinal, a member of the powerful House of Guise. He was known at first as the Cardinal of Guise, and then as the second Cardinal of Lorraine, after the death of his uncle, John, Cardinal of Lorraine (1550). He was the protector of Rabelais and Ronsard and founded Reims University.