Chasing Pain discusses the neuroscientific and clinical evidence that has led to contemporary concepts of pain neurobiology and how pain might emerge from neuronal activity. The limitation of current pain models is exemplified by considering several important, therapeutically challenging clinical conditions that remain very poorly understood. Realistic models of pain neurobiology must consider that the normally tight link between pain and tissue damage is strongly affected by neurological disease, emotionally compelling circumstances, and by complex cognitive processes.
Chasing Pain discusses the neuroscientific and clinical evidence that has led to contemporary concepts of pain neurobiology and how pain might emerge from neuronal activity. The limitation of current pain models is exemplified by considering several important, therapeutically challenging clinical conditions that remain very poorly understood. Realistic models of pain neurobiology must consider that the normally tight link between pain and tissue damage is strongly affected by neurological disease, emotionally compelling circumstances, and by complex cognitive processes.
Kenneth L. Casey, MD is Professor Emeritus of Neurology and Molecular and Integrative Physiology at the University of Michigan in Ann Arbor, Michigan.
Inhaltsangabe
* INTRODUCTION: WHY PAIN? * CHAPTER 1: A SAMPLE AT THE EXTREMES * CHAPTER 2: DRIVERS OF PAIN RESEARCH AND A MEETING IN ISSAQUAH * CHAPTER 3: Functional localization, the spinothalamic tract, and neurosurgery for pain * CHAPTER 4: Emotions, affect, and the limbic system * CHAPTER 5: EARLY EVIDENCE OF CNS CONTROL and A CONCEPTUAL MODEL REVISITED * CHAPTER 6: Psychophysics AND nociceptors * CHAPTER 7: Central sensitization AND PAIN GENES * CHAPTER 8: CNS MODULATION OF PAIN: NEUROPHYSIOLOGICAL AND CLINICAL EVIDENCE * CHAPTER 9: CNS GENERATION AND MODULATION OF PAIN; EARLY EVIDENCE FROM ANATOMICAL BRAIN IMAGING AND THE DEVELOPMENT OF FUNCTIONAL BRAIN IMAGING * CHAPTER 10: FUNCTIONAL IMAGING CONTRIBUTIONS TO CHASING PAIN * CHAPTER 11: UNFINISHED BUSINESS: A SAMPLE * CHAPTER 12: THE CHASE TODAY: SUMMARY AND IMPLICATIONS * Appendix
* INTRODUCTION: WHY PAIN? * CHAPTER 1: A SAMPLE AT THE EXTREMES * CHAPTER 2: DRIVERS OF PAIN RESEARCH AND A MEETING IN ISSAQUAH * CHAPTER 3: Functional localization, the spinothalamic tract, and neurosurgery for pain * CHAPTER 4: Emotions, affect, and the limbic system * CHAPTER 5: EARLY EVIDENCE OF CNS CONTROL and A CONCEPTUAL MODEL REVISITED * CHAPTER 6: Psychophysics AND nociceptors * CHAPTER 7: Central sensitization AND PAIN GENES * CHAPTER 8: CNS MODULATION OF PAIN: NEUROPHYSIOLOGICAL AND CLINICAL EVIDENCE * CHAPTER 9: CNS GENERATION AND MODULATION OF PAIN; EARLY EVIDENCE FROM ANATOMICAL BRAIN IMAGING AND THE DEVELOPMENT OF FUNCTIONAL BRAIN IMAGING * CHAPTER 10: FUNCTIONAL IMAGING CONTRIBUTIONS TO CHASING PAIN * CHAPTER 11: UNFINISHED BUSINESS: A SAMPLE * CHAPTER 12: THE CHASE TODAY: SUMMARY AND IMPLICATIONS * Appendix
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