Edited by the world leaders in this emerging field, this three-volume handbook is designed to become the landmark reference on this exciting new branch of chemistry and biology.Following an introductory section, the authors discuss the use of small molecules to explore biology, discovering small molecule probes for biological mechanisms and expanding the scope of chemical synthesis. Further sections cover chemical informatics, drug discovery and systems biology, and the whole work is rounded off by the outlook and perspectives for this field.No academic institution or pharmaceutical company can possibly miss out on this highly authoritative work.…mehr
Edited by the world leaders in this emerging field, this three-volume handbook is designed to become the landmark reference on this exciting new branch of chemistry and biology.Following an introductory section, the authors discuss the use of small molecules to explore biology, discovering small molecule probes for biological mechanisms and expanding the scope of chemical synthesis. Further sections cover chemical informatics, drug discovery and systems biology, and the whole work is rounded off by the outlook and perspectives for this field.No academic institution or pharmaceutical company can possibly miss out on this highly authoritative work.
Stuart L. Schreiber is the Chair of the Department of Chemistry and Chemical Biology at Harvard University (Boston). He is also a co-founder of the Broad Institute, a joint initiative of Harvard University and MIT. For his pioneering achievements in establishing chemical biology as a new field in chemistry, Professor Schreiber has received numerous awards, among them the ACS Awards in Synthetic Organic Chemistry (1994), and Bioorganic Chemistry (2000), and the Tetrahedron Prize for Creativity in Organic Chemistry (1997). Tarun Kapoor is the Head of the Laboratory of Chemistry and Cell Biology at Rockefeller University (New York). He joined the Rockefeller faculty in 2001 after a postdoctorate with Stuart Schreiber at Harvard University. Research in the Kapoor laboratory focuses on the discovery of small molecule probes for cell division using diversity-oriented synthesis. Günther Wess is the Head of the GSF Institute for Health and Environment in Neuherberg (Germany). Before being appointed to that position, he was the Head of Research and Development Europe of the Sanofi-Aventis corporation. Under his leadership at Aventis, the principles of Chemical Biology have become indispensable for answering basic questions in early drug discovery.
Inhaltsangabe
INTRODUCTION
USING SMALL MOLECULES TO EXPLORE BIOLOGY
- Using natural products to unravel biological mechanisms
- Engineering control over protein function using chemistry
- Controlling protein-protein interactions
- Expanding the genetic code
DISCOVERING SMALL MOLECULE PROBES FOR BIOLOGICAL MECHANISMS
