Chemical Genomics
Herausgeber: Fu, Haian
Chemical Genomics
Herausgeber: Fu, Haian
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This is an edited text on new techniques and applications in chemical genomics for researchers, professionals, and graduate students in biology, biomedicine, and chemistry.
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This is an edited text on new techniques and applications in chemical genomics for researchers, professionals, and graduate students in biology, biomedicine, and chemistry.
Produktdetails
- Produktdetails
- Verlag: Cambridge University Press
- Seitenzahl: 358
- Erscheinungstermin: 3. Mai 2012
- Englisch
- Abmessung: 286mm x 221mm x 24mm
- Gewicht: 1162g
- ISBN-13: 9780521889483
- ISBN-10: 0521889480
- Artikelnr.: 33765179
- Verlag: Cambridge University Press
- Seitenzahl: 358
- Erscheinungstermin: 3. Mai 2012
- Englisch
- Abmessung: 286mm x 221mm x 24mm
- Gewicht: 1162g
- ISBN-13: 9780521889483
- ISBN-10: 0521889480
- Artikelnr.: 33765179
Part I. Overviews: 1. Harnessing the power of chemistry for biology and
medicine Cheryl L. Meyerkord and Haian Fu; 2. Chemical genomics: exploring
biology with small organic molecules Nicholas Aberle and Craig M. Crews; 3.
Chemical proteomics Akihisa Matsuyama, Yoko Yashiroda and Minoru Yoshida;
Part II. Molecules for Chemical Genomics: 4. Diversity-oriented synthesis
Warren R. J. D. Galloway, Richard J. Spandl, Andreas Bender, Gemma L.
Thomas, Monica Diaz-Gavilan, Kieron M. G. O'Connell and David R. Spring; 5.
Targeted chemical libraries Gregory P. Tochtrop and Ryan E. Looper; 6.
Fragment-based ligand discovery Sandra Bartoli, Antonella Squarcia and
Daniela Fattori; 7. Basics and principles for building natural
product-based libraries for HTS Ronald J. Quinn; Part III. Basics of High
Throughput Screening: 8. Essentials for high throughput screening
operations Stewart P. Rudnicki, James V. Follen, Nicola J. Tolliday and
Caroline E. Shamu; 9. High content analysis and screening: basics,
instrumentation and applications Paul A. Johnston; 10. Phenotypic screens
with model organisms Grant N. Wheeler, Robert A. Field and Matthew L.
Tomlinson; 11. Screening informatics and ChemInformatics Lestyn Lewis; Part
IV. Chemical Genomics Assays and Screens: 12. Basics on HTS assay design
and optimization Eduard Sergienko; 13. Molecular sensors for
transcriptional and post-transcriptional assays Douglas S. Auld and Natasha
Thorne; 14. Fluorescence-based platforms for HTS assays ¿ FP and TR-FRET
Yuhong Du and Jonathan Havel; 15. Compound profiling with high content
screening methodology Thomas Mayer and Stephan Schürer; 16. Use of
transgenic zebrafish in a phenotypic screen for angiogenesis inhibitors
Jaeki Min, Yuhong Du, Brenda Bondesen, Brian Revennaugh, Peter Eimon and
Ray Dingledine; 17. Flow cytometry multiplexed screening methodologies
Virginia M. Salas, J. Jacob Strouse, Zurab Surviladze, Irena
Ivnitski-Steele, Bruce S. Edwards and Larry A. Sklar; 18. Basic principles
and practices of computer-aided screening and drug design Chao-Yie Yang,
Denzil Bernard and Shaomeng Wang; 19. Computational approach for drug
target identification Honglin Li, Mingyue Zheng, Xiaofeng Liu and Hualiang
Jiang; 20. Label-free biosensor technologies for assay development and HTS
Yuhong Du and Arron Xu; Part V. Chemical Genomics and Medicine: 21.
Pharmacogenomics to link genetic background with therapeutic efficacy and
safety Mark M. Bouzyk, Weining Tang and Brian Leyland-Jones; 22. Drugs,
genomic response signatures, and customized cancer therapy Rafael Rosell,
Teresa Moran and Miguel Taron; Appendix. Current drug targets and the
druggable genome Andreas Russ.
medicine Cheryl L. Meyerkord and Haian Fu; 2. Chemical genomics: exploring
biology with small organic molecules Nicholas Aberle and Craig M. Crews; 3.
Chemical proteomics Akihisa Matsuyama, Yoko Yashiroda and Minoru Yoshida;
Part II. Molecules for Chemical Genomics: 4. Diversity-oriented synthesis
Warren R. J. D. Galloway, Richard J. Spandl, Andreas Bender, Gemma L.
Thomas, Monica Diaz-Gavilan, Kieron M. G. O'Connell and David R. Spring; 5.
Targeted chemical libraries Gregory P. Tochtrop and Ryan E. Looper; 6.
Fragment-based ligand discovery Sandra Bartoli, Antonella Squarcia and
Daniela Fattori; 7. Basics and principles for building natural
product-based libraries for HTS Ronald J. Quinn; Part III. Basics of High
Throughput Screening: 8. Essentials for high throughput screening
operations Stewart P. Rudnicki, James V. Follen, Nicola J. Tolliday and
Caroline E. Shamu; 9. High content analysis and screening: basics,
instrumentation and applications Paul A. Johnston; 10. Phenotypic screens
with model organisms Grant N. Wheeler, Robert A. Field and Matthew L.
Tomlinson; 11. Screening informatics and ChemInformatics Lestyn Lewis; Part
IV. Chemical Genomics Assays and Screens: 12. Basics on HTS assay design
and optimization Eduard Sergienko; 13. Molecular sensors for
transcriptional and post-transcriptional assays Douglas S. Auld and Natasha
Thorne; 14. Fluorescence-based platforms for HTS assays ¿ FP and TR-FRET
Yuhong Du and Jonathan Havel; 15. Compound profiling with high content
screening methodology Thomas Mayer and Stephan Schürer; 16. Use of
transgenic zebrafish in a phenotypic screen for angiogenesis inhibitors
Jaeki Min, Yuhong Du, Brenda Bondesen, Brian Revennaugh, Peter Eimon and
Ray Dingledine; 17. Flow cytometry multiplexed screening methodologies
Virginia M. Salas, J. Jacob Strouse, Zurab Surviladze, Irena
Ivnitski-Steele, Bruce S. Edwards and Larry A. Sklar; 18. Basic principles
and practices of computer-aided screening and drug design Chao-Yie Yang,
Denzil Bernard and Shaomeng Wang; 19. Computational approach for drug
target identification Honglin Li, Mingyue Zheng, Xiaofeng Liu and Hualiang
Jiang; 20. Label-free biosensor technologies for assay development and HTS
Yuhong Du and Arron Xu; Part V. Chemical Genomics and Medicine: 21.
Pharmacogenomics to link genetic background with therapeutic efficacy and
safety Mark M. Bouzyk, Weining Tang and Brian Leyland-Jones; 22. Drugs,
genomic response signatures, and customized cancer therapy Rafael Rosell,
Teresa Moran and Miguel Taron; Appendix. Current drug targets and the
druggable genome Andreas Russ.
Part I. Overviews: 1. Harnessing the power of chemistry for biology and
medicine Cheryl L. Meyerkord and Haian Fu; 2. Chemical genomics: exploring
biology with small organic molecules Nicholas Aberle and Craig M. Crews; 3.
Chemical proteomics Akihisa Matsuyama, Yoko Yashiroda and Minoru Yoshida;
Part II. Molecules for Chemical Genomics: 4. Diversity-oriented synthesis
Warren R. J. D. Galloway, Richard J. Spandl, Andreas Bender, Gemma L.
Thomas, Monica Diaz-Gavilan, Kieron M. G. O'Connell and David R. Spring; 5.
Targeted chemical libraries Gregory P. Tochtrop and Ryan E. Looper; 6.
Fragment-based ligand discovery Sandra Bartoli, Antonella Squarcia and
Daniela Fattori; 7. Basics and principles for building natural
product-based libraries for HTS Ronald J. Quinn; Part III. Basics of High
Throughput Screening: 8. Essentials for high throughput screening
operations Stewart P. Rudnicki, James V. Follen, Nicola J. Tolliday and
Caroline E. Shamu; 9. High content analysis and screening: basics,
instrumentation and applications Paul A. Johnston; 10. Phenotypic screens
with model organisms Grant N. Wheeler, Robert A. Field and Matthew L.
Tomlinson; 11. Screening informatics and ChemInformatics Lestyn Lewis; Part
IV. Chemical Genomics Assays and Screens: 12. Basics on HTS assay design
and optimization Eduard Sergienko; 13. Molecular sensors for
transcriptional and post-transcriptional assays Douglas S. Auld and Natasha
Thorne; 14. Fluorescence-based platforms for HTS assays ¿ FP and TR-FRET
Yuhong Du and Jonathan Havel; 15. Compound profiling with high content
screening methodology Thomas Mayer and Stephan Schürer; 16. Use of
transgenic zebrafish in a phenotypic screen for angiogenesis inhibitors
Jaeki Min, Yuhong Du, Brenda Bondesen, Brian Revennaugh, Peter Eimon and
Ray Dingledine; 17. Flow cytometry multiplexed screening methodologies
Virginia M. Salas, J. Jacob Strouse, Zurab Surviladze, Irena
Ivnitski-Steele, Bruce S. Edwards and Larry A. Sklar; 18. Basic principles
and practices of computer-aided screening and drug design Chao-Yie Yang,
Denzil Bernard and Shaomeng Wang; 19. Computational approach for drug
target identification Honglin Li, Mingyue Zheng, Xiaofeng Liu and Hualiang
Jiang; 20. Label-free biosensor technologies for assay development and HTS
Yuhong Du and Arron Xu; Part V. Chemical Genomics and Medicine: 21.
Pharmacogenomics to link genetic background with therapeutic efficacy and
safety Mark M. Bouzyk, Weining Tang and Brian Leyland-Jones; 22. Drugs,
genomic response signatures, and customized cancer therapy Rafael Rosell,
Teresa Moran and Miguel Taron; Appendix. Current drug targets and the
druggable genome Andreas Russ.
medicine Cheryl L. Meyerkord and Haian Fu; 2. Chemical genomics: exploring
biology with small organic molecules Nicholas Aberle and Craig M. Crews; 3.
Chemical proteomics Akihisa Matsuyama, Yoko Yashiroda and Minoru Yoshida;
Part II. Molecules for Chemical Genomics: 4. Diversity-oriented synthesis
Warren R. J. D. Galloway, Richard J. Spandl, Andreas Bender, Gemma L.
Thomas, Monica Diaz-Gavilan, Kieron M. G. O'Connell and David R. Spring; 5.
Targeted chemical libraries Gregory P. Tochtrop and Ryan E. Looper; 6.
Fragment-based ligand discovery Sandra Bartoli, Antonella Squarcia and
Daniela Fattori; 7. Basics and principles for building natural
product-based libraries for HTS Ronald J. Quinn; Part III. Basics of High
Throughput Screening: 8. Essentials for high throughput screening
operations Stewart P. Rudnicki, James V. Follen, Nicola J. Tolliday and
Caroline E. Shamu; 9. High content analysis and screening: basics,
instrumentation and applications Paul A. Johnston; 10. Phenotypic screens
with model organisms Grant N. Wheeler, Robert A. Field and Matthew L.
Tomlinson; 11. Screening informatics and ChemInformatics Lestyn Lewis; Part
IV. Chemical Genomics Assays and Screens: 12. Basics on HTS assay design
and optimization Eduard Sergienko; 13. Molecular sensors for
transcriptional and post-transcriptional assays Douglas S. Auld and Natasha
Thorne; 14. Fluorescence-based platforms for HTS assays ¿ FP and TR-FRET
Yuhong Du and Jonathan Havel; 15. Compound profiling with high content
screening methodology Thomas Mayer and Stephan Schürer; 16. Use of
transgenic zebrafish in a phenotypic screen for angiogenesis inhibitors
Jaeki Min, Yuhong Du, Brenda Bondesen, Brian Revennaugh, Peter Eimon and
Ray Dingledine; 17. Flow cytometry multiplexed screening methodologies
Virginia M. Salas, J. Jacob Strouse, Zurab Surviladze, Irena
Ivnitski-Steele, Bruce S. Edwards and Larry A. Sklar; 18. Basic principles
and practices of computer-aided screening and drug design Chao-Yie Yang,
Denzil Bernard and Shaomeng Wang; 19. Computational approach for drug
target identification Honglin Li, Mingyue Zheng, Xiaofeng Liu and Hualiang
Jiang; 20. Label-free biosensor technologies for assay development and HTS
Yuhong Du and Arron Xu; Part V. Chemical Genomics and Medicine: 21.
Pharmacogenomics to link genetic background with therapeutic efficacy and
safety Mark M. Bouzyk, Weining Tang and Brian Leyland-Jones; 22. Drugs,
genomic response signatures, and customized cancer therapy Rafael Rosell,
Teresa Moran and Miguel Taron; Appendix. Current drug targets and the
druggable genome Andreas Russ.