This is an edited text on new techniques and applications in chemical genomics for researchers, professionals, and graduate students in biology, biomedicine, and chemistry.
This is an edited text on new techniques and applications in chemical genomics for researchers, professionals, and graduate students in biology, biomedicine, and chemistry.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Part I. Overviews: 1. Harnessing the power of chemistry for biology and medicine Cheryl L. Meyerkord and Haian Fu; 2. Chemical genomics: exploring biology with small organic molecules Nicholas Aberle and Craig M. Crews; 3. Chemical proteomics Akihisa Matsuyama, Yoko Yashiroda and Minoru Yoshida; Part II. Molecules for Chemical Genomics: 4. Diversity-oriented synthesis Warren R. J. D. Galloway, Richard J. Spandl, Andreas Bender, Gemma L. Thomas, Monica Diaz-Gavilan, Kieron M. G. O'Connell and David R. Spring; 5. Targeted chemical libraries Gregory P. Tochtrop and Ryan E. Looper; 6. Fragment-based ligand discovery Sandra Bartoli, Antonella Squarcia and Daniela Fattori; 7. Basics and principles for building natural product-based libraries for HTS Ronald J. Quinn; Part III. Basics of High Throughput Screening: 8. Essentials for high throughput screening operations Stewart P. Rudnicki, James V. Follen, Nicola J. Tolliday and Caroline E. Shamu; 9. High content analysis and screening: basics, instrumentation and applications Paul A. Johnston; 10. Phenotypic screens with model organisms Grant N. Wheeler, Robert A. Field and Matthew L. Tomlinson; 11. Screening informatics and ChemInformatics Lestyn Lewis; Part IV. Chemical Genomics Assays and Screens: 12. Basics on HTS assay design and optimization Eduard Sergienko; 13. Molecular sensors for transcriptional and post-transcriptional assays Douglas S. Auld and Natasha Thorne; 14. Fluorescence-based platforms for HTS assays - FP and TR-FRET Yuhong Du and Jonathan Havel; 15. Compound profiling with high content screening methodology Thomas Mayer and Stephan Schürer; 16. Use of transgenic zebrafish in a phenotypic screen for angiogenesis inhibitors Jaeki Min, Yuhong Du, Brenda Bondesen, Brian Revennaugh, Peter Eimon and Ray Dingledine; 17. Flow cytometry multiplexed screening methodologies Virginia M. Salas, J. Jacob Strouse, Zurab Surviladze, Irena Ivnitski-Steele, Bruce S. Edwards and Larry A. Sklar; 18. Basic principles and practices of computer-aided screening and drug design Chao-Yie Yang, Denzil Bernard and Shaomeng Wang; 19. Computational approach for drug target identification Honglin Li, Mingyue Zheng, Xiaofeng Liu and Hualiang Jiang; 20. Label-free biosensor technologies for assay development and HTS Yuhong Du and Arron Xu; Part V. Chemical Genomics and Medicine: 21. Pharmacogenomics to link genetic background with therapeutic efficacy and safety Mark M. Bouzyk, Weining Tang and Brian Leyland-Jones; 22. Drugs, genomic response signatures, and customized cancer therapy Rafael Rosell, Teresa Moran and Miguel Taron; Appendix. Current drug targets and the druggable genome Andreas Russ.
Part I. Overviews: 1. Harnessing the power of chemistry for biology and medicine Cheryl L. Meyerkord and Haian Fu; 2. Chemical genomics: exploring biology with small organic molecules Nicholas Aberle and Craig M. Crews; 3. Chemical proteomics Akihisa Matsuyama, Yoko Yashiroda and Minoru Yoshida; Part II. Molecules for Chemical Genomics: 4. Diversity-oriented synthesis Warren R. J. D. Galloway, Richard J. Spandl, Andreas Bender, Gemma L. Thomas, Monica Diaz-Gavilan, Kieron M. G. O'Connell and David R. Spring; 5. Targeted chemical libraries Gregory P. Tochtrop and Ryan E. Looper; 6. Fragment-based ligand discovery Sandra Bartoli, Antonella Squarcia and Daniela Fattori; 7. Basics and principles for building natural product-based libraries for HTS Ronald J. Quinn; Part III. Basics of High Throughput Screening: 8. Essentials for high throughput screening operations Stewart P. Rudnicki, James V. Follen, Nicola J. Tolliday and Caroline E. Shamu; 9. High content analysis and screening: basics, instrumentation and applications Paul A. Johnston; 10. Phenotypic screens with model organisms Grant N. Wheeler, Robert A. Field and Matthew L. Tomlinson; 11. Screening informatics and ChemInformatics Lestyn Lewis; Part IV. Chemical Genomics Assays and Screens: 12. Basics on HTS assay design and optimization Eduard Sergienko; 13. Molecular sensors for transcriptional and post-transcriptional assays Douglas S. Auld and Natasha Thorne; 14. Fluorescence-based platforms for HTS assays - FP and TR-FRET Yuhong Du and Jonathan Havel; 15. Compound profiling with high content screening methodology Thomas Mayer and Stephan Schürer; 16. Use of transgenic zebrafish in a phenotypic screen for angiogenesis inhibitors Jaeki Min, Yuhong Du, Brenda Bondesen, Brian Revennaugh, Peter Eimon and Ray Dingledine; 17. Flow cytometry multiplexed screening methodologies Virginia M. Salas, J. Jacob Strouse, Zurab Surviladze, Irena Ivnitski-Steele, Bruce S. Edwards and Larry A. Sklar; 18. Basic principles and practices of computer-aided screening and drug design Chao-Yie Yang, Denzil Bernard and Shaomeng Wang; 19. Computational approach for drug target identification Honglin Li, Mingyue Zheng, Xiaofeng Liu and Hualiang Jiang; 20. Label-free biosensor technologies for assay development and HTS Yuhong Du and Arron Xu; Part V. Chemical Genomics and Medicine: 21. Pharmacogenomics to link genetic background with therapeutic efficacy and safety Mark M. Bouzyk, Weining Tang and Brian Leyland-Jones; 22. Drugs, genomic response signatures, and customized cancer therapy Rafael Rosell, Teresa Moran and Miguel Taron; Appendix. Current drug targets and the druggable genome Andreas Russ.
Es gelten unsere Allgemeinen Geschäftsbedingungen: www.buecher.de/agb
Impressum
www.buecher.de ist ein Internetauftritt der buecher.de internetstores GmbH
Geschäftsführung: Monica Sawhney | Roland Kölbl | Günter Hilger
Sitz der Gesellschaft: Batheyer Straße 115 - 117, 58099 Hagen
Postanschrift: Bürgermeister-Wegele-Str. 12, 86167 Augsburg
Amtsgericht Hagen HRB 13257
Steuernummer: 321/5800/1497
USt-IdNr: DE450055826
