Chemistry and Antimicrobial Potential of Thienopyrimidinones - Singh, S D;KUMAR, ARVIND;Tiwari, S B
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Thienopyrimidinones are the bioisoster of quinazoline heterocyclics and unlike quinazoline, it exists in three possible annulations of thiophene to the pyrimidine ring viz thieno[2,3-d] pyrimidine, thieno[3,2-d]pyrimidine and thieno[3,4-d]pyrimidine. Thienopyrimidinones moiety exhibits various activities like analgesic, antihypertensive, platelet aggregation inhibitors, antiprotozoal, a bronchodilator, phosphodiesterase inhibitor and antihistaminic activities. The antimicrobial activity of some novel Thienopyrimidinones derivatives have been evaluated as per the standard protocol and all the…mehr

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Produktbeschreibung
Thienopyrimidinones are the bioisoster of quinazoline heterocyclics and unlike quinazoline, it exists in three possible annulations of thiophene to the pyrimidine ring viz thieno[2,3-d] pyrimidine, thieno[3,2-d]pyrimidine and thieno[3,4-d]pyrimidine. Thienopyrimidinones moiety exhibits various activities like analgesic, antihypertensive, platelet aggregation inhibitors, antiprotozoal, a bronchodilator, phosphodiesterase inhibitor and antihistaminic activities. The antimicrobial activity of some novel Thienopyrimidinones derivatives have been evaluated as per the standard protocol and all the derivatives are found to be equally potent like a standard drug.
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Autorenporträt
Dr. S D Singh, Former Head, Department of Pharmacy, MJP Rohilkhand University, Bareilly (UP) possesses more than 22 years of teaching and research experience with a specialization in medicinal chemistry and analytical chemistry. He is also a recipient of the Teacher's award by the UP government for the implementation of the new education policy.