Chemistry and Biochemistry of Oxygen Therapeutics
From Transfusion to Artificial Blood
Herausgeber: Mozzarelli, Andrea; Bettati, Stefano
Schade – dieser Artikel ist leider ausverkauft. Sobald wir wissen, ob und wann der Artikel wieder verfügbar ist, informieren wir Sie an dieser Stelle.
Chemistry and Biochemistry of Oxygen Therapeutics
From Transfusion to Artificial Blood
Herausgeber: Mozzarelli, Andrea; Bettati, Stefano
- Gebundenes Buch
- Merkliste
- Auf die Merkliste
- Bewerten Bewerten
- Teilen
- Produkt teilen
- Produkterinnerung
- Produkterinnerung
Scientists are developing oxygen therapeutics, or "blood substitutes," with the same oxygen-carrying capability as blood, that can be used as replacements for blood transfusion or to treat diseases where oxygen transport is impaired. This book links the underlying biochemical principles of the field with chemical and biotechnological innovations and pre-clinical development, starting with the observation that an oxygen therapeutic agent can be developed only upon a deep understanding of oxygen and nitric oxide, homeostasis and regulation, and the well-documented correlations between adverse…mehr
Andere Kunden interessierten sich auch für
Scientists are developing oxygen therapeutics, or "blood substitutes," with the same oxygen-carrying capability as blood, that can be used as replacements for blood transfusion or to treat diseases where oxygen transport is impaired. This book links the underlying biochemical principles of the field with chemical and biotechnological innovations and pre-clinical development, starting with the observation that an oxygen therapeutic agent can be developed only upon a deep understanding of oxygen and nitric oxide, homeostasis and regulation, and the well-documented correlations between adverse effects of a specific product and its biochemical-physiological properties.
Produktdetails
- Produktdetails
- Verlag: John Wiley & Sons / Wiley
- Seitenzahl: 466
- Erscheinungstermin: 13. September 2011
- Englisch
- Abmessung: 252mm x 174mm x 29mm
- Gewicht: 964g
- ISBN-13: 9780470686683
- ISBN-10: 0470686685
- Artikelnr.: 33257371
- Verlag: John Wiley & Sons / Wiley
- Seitenzahl: 466
- Erscheinungstermin: 13. September 2011
- Englisch
- Abmessung: 252mm x 174mm x 29mm
- Gewicht: 964g
- ISBN-13: 9780470686683
- ISBN-10: 0470686685
- Artikelnr.: 33257371
Professor Andrea Mozzarelli, Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Parma, Italy Andrea Mozzarelli is Full Professor of Biochemistry in the Pharmacy Faculty at the University of Parma, teaching general and applied Biochemistry. He is Member of the International Advisory Board for Vitamin B6, PQQ, Carbonyl Catalysis and Quinoproteins Meetings, and was scientific organizer of the international courses on "From Structural Genomics to Drug Discovery" held at the University of Parma in 2000, 2002 and 2004. Between 2004 and 2006 Professor Mozzarrelli was head of a research unit of a EU funded project on "EuroBlood substitutes". He is President of the XII International Symposium on Blood Substitutes, to be held in Parma, Italy, on August 25-28, 2009 (http: //alice.bio.unipr.it/blood2009/). Professor Stefano Bettati, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Parma, Italy.
List of Contributors xvii Preface xxiii 1. Introduction 1 Richard B.
Weiskopf References 5 Part I. Oxygen: Chemistry, Biochemistry, Physiology
and Toxicity 9 2. Hemoglobin Reactivity and Regulation 11 Stefano Bettati
and Andrea Mozzarelli Natural and Engineered Hbs 17 Acknowledgments 19
References 19 3. The Major Physiological Control Mechanisms of Blood Flow
and Oxygen Delivery 23 Raymond C. Koehler References 39 4. The Main
Players: Hemoglobin and Myoglobin; Nitric Oxide and Oxygen 47 Tim J.
McMahon and Joseph Bonaventura Acknowledgments 58 References 59 5. The Role
of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury 63
Ester Spagnolli and Warren M. Zapol Acknowledgments 72 References 72 Part
II. Medical Needs for Oxygen Supply 79 6. Acute Traumatic Hemorrhage and
Anemia 81 Lena M. Napolitano References 97 7. Diagnosis and Treatment of
Haemorrhages in 'Nonsurgical' Patients 107 Umberto Rossi and Rosa Chianese
Further Reading 118 8. Management of Perioperative Bleeding 121 Sibylle A.
Kozek-Langenecker References 127 9. Oxygenation in the Preterm Neonate 131
Vidheya Venkatesh, Priya Muthukumar, Anna Curley and Simon Stanworth
References 138 10. Ischemia 145 Hooman Mirzakhani and Ala Nozari References
153 11. Normobaric and Hyperbaric Oxygen Therapy for Ischemic Stroke and
Other Neurological Conditions 159 Ari Moskowitz, Yu-Feng Yvonne Chan and
Aneesh B. Singhal References 170 12. Transfusion Therapy in ² Thalassemia
and Sickle Cell Disease 179 Carlo Brugnara and Lucia De Franceschi
References 186 Part III. "Old" and New Strategies for Oxygen Supply 193 13.
Transfusion: Political, Administrative and Logistic Issues 195 John R. Hess
and Giuliano Grazzini Disclaimer 195 References 202 14. Conscientious
Objection in Patient Blood Management 205 Kenneth E. Nollet and Hitoshi
Ohto Acknowledgements 209 References 210 15. Red-cell Transfusion in
Clinical Practice 213 Harvey G. Klein Disclaimer 218 References 218 16.
Causes and Consequences of Red Cell Incompatibility 221 Chisa Yamada and
Robertson Davenport References 228 17. Biochemistry of Storage of Red Blood
Cells 231 Ryan Stapley, Dario A. Vitturi and Rakesh P. Patel
Acknowledgements 238 References 238 18. Proteomic Investigations of Stored
Red Blood Cells 243 Lello Zolla and Angelo D'Alessandro References 252 19.
Red Blood Cells from Stem Cells 257 Anna Rita Migliaccio, Carolyn Whitsett
and Giovanni Migliaccio References 268 20. The Universal Red Blood Cell 273
Luca Ronda and Serena Faggiano References 280 21. Allosteric Effectors of
Hemoglobin: Past, Present and Future 285 Martin K. Safo and Stefano Bruno
References 296 22. Hemoglobin-based Oxygen Carriers: History, Limits, Brief
Summary of the State of the Art, Including Clinical Trials 301 Jonathan S.
Jahr, Arezou Sadighi, Linzy Doherty, Alvin Li and Hae Won Kim References
314 23. Oxygen Delivery by Natural and Artificial Oxygen Carriers 317
Enrico Bucci Acknowledgments 324 References 324 24. Crosslinked and
Polymerized Hemoglobins as Potential Blood Substitutes 327 Kenneth W. Olsen
and Eugene Tarasov References 338 25. Engineering the Molecular Shape of
PEG-Hemoglobin Adducts for Supraperfusion 345 Seetharama A. Acharya, Marcos
Intaglietta, Amy G. Tsai, Kulal Ananda and Fantao Meng Acknowledgments 366
References 367 26. Hb Octamers by Introduction of Surface Cysteines 371
V¿eronique Baudin-Creuza, Chien Ho and Michael C. Marden References 378 27.
Hemoglobin Vesicles as a Cellular-type Hemoglobin-based Oxygen Carrier 381
Hiromi Sakai, Hirohisa Horinouchi, Eishun Tsuchida and Koichi Kobayashi
Acknowledgments 387 References 387 28. Animal Models and Oxidative
Biomarkers to Evaluate Preclinical Safety of Extracellular Hemoglobins 391
Paul W. Buehler and Felice D'Agnillo Disclaimer 391 References 405 29.
Academia-Industry Collaboration in Blood Substitute Development: Issues,
Case Histories and a Proposal 413 Hae Won Kim, Andrea Mozzarelli, Hiromi
Sakai and Jonathan S. Jahr Appendix: Successful Academia-Industry
Collaboration Cases in HBOC Development 422 Case A: Waseda-Keio-Industry
Research Collaboration 422 Case B: EuroBloodSubstitutes Consortium 424
References 426 Index 429
Weiskopf References 5 Part I. Oxygen: Chemistry, Biochemistry, Physiology
and Toxicity 9 2. Hemoglobin Reactivity and Regulation 11 Stefano Bettati
and Andrea Mozzarelli Natural and Engineered Hbs 17 Acknowledgments 19
References 19 3. The Major Physiological Control Mechanisms of Blood Flow
and Oxygen Delivery 23 Raymond C. Koehler References 39 4. The Main
Players: Hemoglobin and Myoglobin; Nitric Oxide and Oxygen 47 Tim J.
McMahon and Joseph Bonaventura Acknowledgments 58 References 59 5. The Role
of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury 63
Ester Spagnolli and Warren M. Zapol Acknowledgments 72 References 72 Part
II. Medical Needs for Oxygen Supply 79 6. Acute Traumatic Hemorrhage and
Anemia 81 Lena M. Napolitano References 97 7. Diagnosis and Treatment of
Haemorrhages in 'Nonsurgical' Patients 107 Umberto Rossi and Rosa Chianese
Further Reading 118 8. Management of Perioperative Bleeding 121 Sibylle A.
Kozek-Langenecker References 127 9. Oxygenation in the Preterm Neonate 131
Vidheya Venkatesh, Priya Muthukumar, Anna Curley and Simon Stanworth
References 138 10. Ischemia 145 Hooman Mirzakhani and Ala Nozari References
153 11. Normobaric and Hyperbaric Oxygen Therapy for Ischemic Stroke and
Other Neurological Conditions 159 Ari Moskowitz, Yu-Feng Yvonne Chan and
Aneesh B. Singhal References 170 12. Transfusion Therapy in ² Thalassemia
and Sickle Cell Disease 179 Carlo Brugnara and Lucia De Franceschi
References 186 Part III. "Old" and New Strategies for Oxygen Supply 193 13.
Transfusion: Political, Administrative and Logistic Issues 195 John R. Hess
and Giuliano Grazzini Disclaimer 195 References 202 14. Conscientious
Objection in Patient Blood Management 205 Kenneth E. Nollet and Hitoshi
Ohto Acknowledgements 209 References 210 15. Red-cell Transfusion in
Clinical Practice 213 Harvey G. Klein Disclaimer 218 References 218 16.
Causes and Consequences of Red Cell Incompatibility 221 Chisa Yamada and
Robertson Davenport References 228 17. Biochemistry of Storage of Red Blood
Cells 231 Ryan Stapley, Dario A. Vitturi and Rakesh P. Patel
Acknowledgements 238 References 238 18. Proteomic Investigations of Stored
Red Blood Cells 243 Lello Zolla and Angelo D'Alessandro References 252 19.
Red Blood Cells from Stem Cells 257 Anna Rita Migliaccio, Carolyn Whitsett
and Giovanni Migliaccio References 268 20. The Universal Red Blood Cell 273
Luca Ronda and Serena Faggiano References 280 21. Allosteric Effectors of
Hemoglobin: Past, Present and Future 285 Martin K. Safo and Stefano Bruno
References 296 22. Hemoglobin-based Oxygen Carriers: History, Limits, Brief
Summary of the State of the Art, Including Clinical Trials 301 Jonathan S.
Jahr, Arezou Sadighi, Linzy Doherty, Alvin Li and Hae Won Kim References
314 23. Oxygen Delivery by Natural and Artificial Oxygen Carriers 317
Enrico Bucci Acknowledgments 324 References 324 24. Crosslinked and
Polymerized Hemoglobins as Potential Blood Substitutes 327 Kenneth W. Olsen
and Eugene Tarasov References 338 25. Engineering the Molecular Shape of
PEG-Hemoglobin Adducts for Supraperfusion 345 Seetharama A. Acharya, Marcos
Intaglietta, Amy G. Tsai, Kulal Ananda and Fantao Meng Acknowledgments 366
References 367 26. Hb Octamers by Introduction of Surface Cysteines 371
V¿eronique Baudin-Creuza, Chien Ho and Michael C. Marden References 378 27.
Hemoglobin Vesicles as a Cellular-type Hemoglobin-based Oxygen Carrier 381
Hiromi Sakai, Hirohisa Horinouchi, Eishun Tsuchida and Koichi Kobayashi
Acknowledgments 387 References 387 28. Animal Models and Oxidative
Biomarkers to Evaluate Preclinical Safety of Extracellular Hemoglobins 391
Paul W. Buehler and Felice D'Agnillo Disclaimer 391 References 405 29.
Academia-Industry Collaboration in Blood Substitute Development: Issues,
Case Histories and a Proposal 413 Hae Won Kim, Andrea Mozzarelli, Hiromi
Sakai and Jonathan S. Jahr Appendix: Successful Academia-Industry
Collaboration Cases in HBOC Development 422 Case A: Waseda-Keio-Industry
Research Collaboration 422 Case B: EuroBloodSubstitutes Consortium 424
References 426 Index 429
List of Contributors xvii Preface xxiii 1. Introduction 1 Richard B.
Weiskopf References 5 Part I. Oxygen: Chemistry, Biochemistry, Physiology
and Toxicity 9 2. Hemoglobin Reactivity and Regulation 11 Stefano Bettati
and Andrea Mozzarelli Natural and Engineered Hbs 17 Acknowledgments 19
References 19 3. The Major Physiological Control Mechanisms of Blood Flow
and Oxygen Delivery 23 Raymond C. Koehler References 39 4. The Main
Players: Hemoglobin and Myoglobin; Nitric Oxide and Oxygen 47 Tim J.
McMahon and Joseph Bonaventura Acknowledgments 58 References 59 5. The Role
of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury 63
Ester Spagnolli and Warren M. Zapol Acknowledgments 72 References 72 Part
II. Medical Needs for Oxygen Supply 79 6. Acute Traumatic Hemorrhage and
Anemia 81 Lena M. Napolitano References 97 7. Diagnosis and Treatment of
Haemorrhages in 'Nonsurgical' Patients 107 Umberto Rossi and Rosa Chianese
Further Reading 118 8. Management of Perioperative Bleeding 121 Sibylle A.
Kozek-Langenecker References 127 9. Oxygenation in the Preterm Neonate 131
Vidheya Venkatesh, Priya Muthukumar, Anna Curley and Simon Stanworth
References 138 10. Ischemia 145 Hooman Mirzakhani and Ala Nozari References
153 11. Normobaric and Hyperbaric Oxygen Therapy for Ischemic Stroke and
Other Neurological Conditions 159 Ari Moskowitz, Yu-Feng Yvonne Chan and
Aneesh B. Singhal References 170 12. Transfusion Therapy in ² Thalassemia
and Sickle Cell Disease 179 Carlo Brugnara and Lucia De Franceschi
References 186 Part III. "Old" and New Strategies for Oxygen Supply 193 13.
Transfusion: Political, Administrative and Logistic Issues 195 John R. Hess
and Giuliano Grazzini Disclaimer 195 References 202 14. Conscientious
Objection in Patient Blood Management 205 Kenneth E. Nollet and Hitoshi
Ohto Acknowledgements 209 References 210 15. Red-cell Transfusion in
Clinical Practice 213 Harvey G. Klein Disclaimer 218 References 218 16.
Causes and Consequences of Red Cell Incompatibility 221 Chisa Yamada and
Robertson Davenport References 228 17. Biochemistry of Storage of Red Blood
Cells 231 Ryan Stapley, Dario A. Vitturi and Rakesh P. Patel
Acknowledgements 238 References 238 18. Proteomic Investigations of Stored
Red Blood Cells 243 Lello Zolla and Angelo D'Alessandro References 252 19.
Red Blood Cells from Stem Cells 257 Anna Rita Migliaccio, Carolyn Whitsett
and Giovanni Migliaccio References 268 20. The Universal Red Blood Cell 273
Luca Ronda and Serena Faggiano References 280 21. Allosteric Effectors of
Hemoglobin: Past, Present and Future 285 Martin K. Safo and Stefano Bruno
References 296 22. Hemoglobin-based Oxygen Carriers: History, Limits, Brief
Summary of the State of the Art, Including Clinical Trials 301 Jonathan S.
Jahr, Arezou Sadighi, Linzy Doherty, Alvin Li and Hae Won Kim References
314 23. Oxygen Delivery by Natural and Artificial Oxygen Carriers 317
Enrico Bucci Acknowledgments 324 References 324 24. Crosslinked and
Polymerized Hemoglobins as Potential Blood Substitutes 327 Kenneth W. Olsen
and Eugene Tarasov References 338 25. Engineering the Molecular Shape of
PEG-Hemoglobin Adducts for Supraperfusion 345 Seetharama A. Acharya, Marcos
Intaglietta, Amy G. Tsai, Kulal Ananda and Fantao Meng Acknowledgments 366
References 367 26. Hb Octamers by Introduction of Surface Cysteines 371
V¿eronique Baudin-Creuza, Chien Ho and Michael C. Marden References 378 27.
Hemoglobin Vesicles as a Cellular-type Hemoglobin-based Oxygen Carrier 381
Hiromi Sakai, Hirohisa Horinouchi, Eishun Tsuchida and Koichi Kobayashi
Acknowledgments 387 References 387 28. Animal Models and Oxidative
Biomarkers to Evaluate Preclinical Safety of Extracellular Hemoglobins 391
Paul W. Buehler and Felice D'Agnillo Disclaimer 391 References 405 29.
Academia-Industry Collaboration in Blood Substitute Development: Issues,
Case Histories and a Proposal 413 Hae Won Kim, Andrea Mozzarelli, Hiromi
Sakai and Jonathan S. Jahr Appendix: Successful Academia-Industry
Collaboration Cases in HBOC Development 422 Case A: Waseda-Keio-Industry
Research Collaboration 422 Case B: EuroBloodSubstitutes Consortium 424
References 426 Index 429
Weiskopf References 5 Part I. Oxygen: Chemistry, Biochemistry, Physiology
and Toxicity 9 2. Hemoglobin Reactivity and Regulation 11 Stefano Bettati
and Andrea Mozzarelli Natural and Engineered Hbs 17 Acknowledgments 19
References 19 3. The Major Physiological Control Mechanisms of Blood Flow
and Oxygen Delivery 23 Raymond C. Koehler References 39 4. The Main
Players: Hemoglobin and Myoglobin; Nitric Oxide and Oxygen 47 Tim J.
McMahon and Joseph Bonaventura Acknowledgments 58 References 59 5. The Role
of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury 63
Ester Spagnolli and Warren M. Zapol Acknowledgments 72 References 72 Part
II. Medical Needs for Oxygen Supply 79 6. Acute Traumatic Hemorrhage and
Anemia 81 Lena M. Napolitano References 97 7. Diagnosis and Treatment of
Haemorrhages in 'Nonsurgical' Patients 107 Umberto Rossi and Rosa Chianese
Further Reading 118 8. Management of Perioperative Bleeding 121 Sibylle A.
Kozek-Langenecker References 127 9. Oxygenation in the Preterm Neonate 131
Vidheya Venkatesh, Priya Muthukumar, Anna Curley and Simon Stanworth
References 138 10. Ischemia 145 Hooman Mirzakhani and Ala Nozari References
153 11. Normobaric and Hyperbaric Oxygen Therapy for Ischemic Stroke and
Other Neurological Conditions 159 Ari Moskowitz, Yu-Feng Yvonne Chan and
Aneesh B. Singhal References 170 12. Transfusion Therapy in ² Thalassemia
and Sickle Cell Disease 179 Carlo Brugnara and Lucia De Franceschi
References 186 Part III. "Old" and New Strategies for Oxygen Supply 193 13.
Transfusion: Political, Administrative and Logistic Issues 195 John R. Hess
and Giuliano Grazzini Disclaimer 195 References 202 14. Conscientious
Objection in Patient Blood Management 205 Kenneth E. Nollet and Hitoshi
Ohto Acknowledgements 209 References 210 15. Red-cell Transfusion in
Clinical Practice 213 Harvey G. Klein Disclaimer 218 References 218 16.
Causes and Consequences of Red Cell Incompatibility 221 Chisa Yamada and
Robertson Davenport References 228 17. Biochemistry of Storage of Red Blood
Cells 231 Ryan Stapley, Dario A. Vitturi and Rakesh P. Patel
Acknowledgements 238 References 238 18. Proteomic Investigations of Stored
Red Blood Cells 243 Lello Zolla and Angelo D'Alessandro References 252 19.
Red Blood Cells from Stem Cells 257 Anna Rita Migliaccio, Carolyn Whitsett
and Giovanni Migliaccio References 268 20. The Universal Red Blood Cell 273
Luca Ronda and Serena Faggiano References 280 21. Allosteric Effectors of
Hemoglobin: Past, Present and Future 285 Martin K. Safo and Stefano Bruno
References 296 22. Hemoglobin-based Oxygen Carriers: History, Limits, Brief
Summary of the State of the Art, Including Clinical Trials 301 Jonathan S.
Jahr, Arezou Sadighi, Linzy Doherty, Alvin Li and Hae Won Kim References
314 23. Oxygen Delivery by Natural and Artificial Oxygen Carriers 317
Enrico Bucci Acknowledgments 324 References 324 24. Crosslinked and
Polymerized Hemoglobins as Potential Blood Substitutes 327 Kenneth W. Olsen
and Eugene Tarasov References 338 25. Engineering the Molecular Shape of
PEG-Hemoglobin Adducts for Supraperfusion 345 Seetharama A. Acharya, Marcos
Intaglietta, Amy G. Tsai, Kulal Ananda and Fantao Meng Acknowledgments 366
References 367 26. Hb Octamers by Introduction of Surface Cysteines 371
V¿eronique Baudin-Creuza, Chien Ho and Michael C. Marden References 378 27.
Hemoglobin Vesicles as a Cellular-type Hemoglobin-based Oxygen Carrier 381
Hiromi Sakai, Hirohisa Horinouchi, Eishun Tsuchida and Koichi Kobayashi
Acknowledgments 387 References 387 28. Animal Models and Oxidative
Biomarkers to Evaluate Preclinical Safety of Extracellular Hemoglobins 391
Paul W. Buehler and Felice D'Agnillo Disclaimer 391 References 405 29.
Academia-Industry Collaboration in Blood Substitute Development: Issues,
Case Histories and a Proposal 413 Hae Won Kim, Andrea Mozzarelli, Hiromi
Sakai and Jonathan S. Jahr Appendix: Successful Academia-Industry
Collaboration Cases in HBOC Development 422 Case A: Waseda-Keio-Industry
Research Collaboration 422 Case B: EuroBloodSubstitutes Consortium 424
References 426 Index 429