Chemistry of Iminothiazolidinone Heterocycles - Rafique, Hummera
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Thioureas are exceptionally versatile building blocks towards the synthesis of wide variety of heterocyclic systems, which also possess extensive range of bioactivities. Thiourea derivatives serve as precursors for the synthesis of five membered heterocycles with imino moiety like methyl 2-[2-benzamido-3-(2-benzothiazolyl)-4-oxothiazolidin-5-ylidene]acetates and ethyl 4-[2-benzamido-5-(2-methoxy-2-oxoethylidene)-4-oxothiazolidin-3-yl]benzoates. They were prepared in good yields, by the direct cyclization of these thioureas with dimethyl but-2-ynedioate (DMAD) in methanol. Iminothiazolidinones…mehr

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Produktbeschreibung
Thioureas are exceptionally versatile building blocks towards the synthesis of wide variety of heterocyclic systems, which also possess extensive range of bioactivities. Thiourea derivatives serve as precursors for the synthesis of five membered heterocycles with imino moiety like methyl 2-[2-benzamido-3-(2-benzothiazolyl)-4-oxothiazolidin-5-ylidene]acetates and ethyl 4-[2-benzamido-5-(2-methoxy-2-oxoethylidene)-4-oxothiazolidin-3-yl]benzoates. They were prepared in good yields, by the direct cyclization of these thioureas with dimethyl but-2-ynedioate (DMAD) in methanol. Iminothiazolidinones and their derivatives exhibit a wide variety of chemotherapeutic activities.
Autorenporträt
Dr.Hummera Rafique obtained her Ph.D Degree in Organic Chemistry (Dec-2012) from Quaid-i-Azam University Islamabad, Pakistan. She was awarded French Embassy "Sandwich Ph.D Fellowship" for University of Paris Sud-11 and she had also done a part of her research work at University of Rostock, Germany. She has published more than 20 research articles.