The considerable biological and medicinal activities of quinolines and their derivatives have prompted considerable research aimed at developing synthetic routes to these ring systems.A search contains a selection of the recently reported synthetic routes for the preparation of quinolines and their derivatives and their reactions with different reagents. The intoduction part contains a selection of the recently reported synthetic methods for the preparation of quinolines and their derivatives and their reactions with different reagents and their biological activities.Then in the second part , pyranoquinoline and their derivatives were prepared and we have investigate their reactivity towards different reagents.