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Rectal cancer is one of the most common malignant tumors of GIT. Combining chemotherapy with radiotherapy has a sound effect on its management. By this systematic review and meta-analysis study, we include data of chemoradiation of rectal cancer articles from 2015 until 2019. The research was carried out at Baghdad Medical City oncology centers. Accordance with the PRISMA guidelines, and the Newcastle-Ottawa Scale used. Rectosigmoid represented the most common site and adenocarcinoma was common histopathology with localized stage. The distant from anal verge mostly seen was 5-10 cm. The pulmonary was commonest site of metastasis in 11(10.9%). A total of 2609 articles from 12 databases met our search strategies. The highest Newcastle-Ottawa score (8) demonstrated in three studies, and median score (7) calculated in five studies. Rectosigmoid represented the most common site. Mostly, the 5-10 cm distant of tumor from anal verge was common finding. We concluded the formulation of a novel point that survival benefit found in many pre or postoperative chemoradiation trials in rectal cancer.