Chemosensors-organic molecules designed to bind and sense small molecules or metal ions-function as molecular-level sensors that generate a signal upon binding. Providing a comprehensive background on chemosensors and their synthesis, design, and applications for detecting biological and metal molecules, Chemosensors: Principles, Strategies, and Applications compiles information on sensor design in a single, accessible source. The text highlights applications in drug discovery and catalysis that have not been as well-covered elsewhere, making this an indispensable source of information for chemical, biomedical, and molecular analysts using sensors.…mehr
Chemosensors-organic molecules designed to bind and sense small molecules or metal ions-function as molecular-level sensors that generate a signal upon binding. Providing a comprehensive background on chemosensors and their synthesis, design, and applications for detecting biological and metal molecules, Chemosensors: Principles, Strategies, and Applications compiles information on sensor design in a single, accessible source. The text highlights applications in drug discovery and catalysis that have not been as well-covered elsewhere, making this an indispensable source of information for chemical, biomedical, and molecular analysts using sensors.
BINGHE WANG, PhD, is Professor and Chair of the Department of Chemistry at Georgia State University as well as Georgia Research Alliance Eminent Scholar in Drug Discovery. He is Editor-in-Chief of the journal Medicinal Research Reviews, series editor for the Wiley Series in Drug Discovery and Development, and coeditor of Drug Delivery: Principles and Applications and Carbohydrate Recognition: Biological Problems, Methods, and Applications, both from Wiley. ERIC V. ANSLYN, PhD, is the Norman Hackerman Professor of Chemistry at the University of Texas at Austin. His research interests include physical organic chemistry, molecular recognition, sensor design, and sensor arrays.
Inhaltsangabe
Contributors. Preface. SECTION 1 FORCES GOVERNING EXCHANGEABLE INTERACTIONS. 1 van der Waals Interactions and the Hydrophobic Effect (Bruce C. Gibb). 2 Ionic, Hydrogen Bond, and p -Cation Interactions (Hector Adam Velazquez and Donald Hamelberg). 3 Covalent Interactions in Chemosensor Design (Yunfeng Cheng, Xiaochuan Yang, and Binghe Wang). 4 Metal Chelation Chemistry (Dongwhan Lee). SECTION 2 STRATEGIES TOWARD BUILDING THE DESIRED BINDING MOIETY. 5 Scaffold Design Using Computational Chemistry (Dale Drueckhammer). 6 Combinatorial Search of Sensors (Marc Vendrell, Suihan Feng, and Young-Tae Chang). 7 Molecular Imprinting and Sensor Development (Yagang Zhang and Ken D. Shimizu). 8 Dendrimer-Based Sensors (Lin Pu). 9 Nanoparticles and Sensors (Yi-Cheun Yeh, Sarit S. Agasti, Krishnendu Saha, and Vincent M. Rotello). 10 Aptamer Selection, Phage Display, and Sensor Development (Hui Wang, Yan Chen, and Weihong Tan). 11 Sensor Development Using Existing Scaffolds (Hiroyasu Yamaguchi, Tomoki Ogoshi, and Akira Harada). SECTION 3 DETECTION METHODS IN CHEMOSENSING. 12 Fluorescent Detection Principles and Strategies (Raman Parkesh, Emma B. Veale, and Thorfinnur Gunnlaugsson). 13 New Fluorophore Design (Michael D. Heagy). 14 Colorimetric Sensor Design (Kevin L. Bicker, Sheryl L. Wiskur, and John J. Lavigne). 15 Electrochemical Detection (Simon R. Bayly, George Z. Chen, and Paul D. Beer). 16 Surface Plasmon Resonance and Quartz Crystal Microbalance Methods for Detection of Molecular Interactions (Yang Liu, Archana Jaiswal, Mark A. Poggi, and W. David Wilson). 17 Array-Based Sensors (Pavel Anzenbacher and Manuel A. Palacios). SECTION 4 CHEMOSENSORS: CASE STUDIES. 18 Design of Cation-Selective Synthetic Fluorescent Indicators (Christoph J. Fahrni). 19 Anion Sensors (Philip A. Gale and Claudia Caltagirone). 20 Chemosensors: Case Studies of Indicators for Organic Molecules (Oleksandr Rusin, Jorge O. Escobedo, and Robert M. Strongin). 21 Molecular Recognition Elements for Toxin and Pathogen Detection (Daniel M. Lewallen, Duane M. Hatch, and Suri S. Iyer). 22 Chemical Sensing and Detection in Forensic Science (Simon W. Lewis). Index.
Contributors. Preface. SECTION 1 FORCES GOVERNING EXCHANGEABLE INTERACTIONS. 1 van der Waals Interactions and the Hydrophobic Effect (Bruce C. Gibb). 2 Ionic, Hydrogen Bond, and p -Cation Interactions (Hector Adam Velazquez and Donald Hamelberg). 3 Covalent Interactions in Chemosensor Design (Yunfeng Cheng, Xiaochuan Yang, and Binghe Wang). 4 Metal Chelation Chemistry (Dongwhan Lee). SECTION 2 STRATEGIES TOWARD BUILDING THE DESIRED BINDING MOIETY. 5 Scaffold Design Using Computational Chemistry (Dale Drueckhammer). 6 Combinatorial Search of Sensors (Marc Vendrell, Suihan Feng, and Young-Tae Chang). 7 Molecular Imprinting and Sensor Development (Yagang Zhang and Ken D. Shimizu). 8 Dendrimer-Based Sensors (Lin Pu). 9 Nanoparticles and Sensors (Yi-Cheun Yeh, Sarit S. Agasti, Krishnendu Saha, and Vincent M. Rotello). 10 Aptamer Selection, Phage Display, and Sensor Development (Hui Wang, Yan Chen, and Weihong Tan). 11 Sensor Development Using Existing Scaffolds (Hiroyasu Yamaguchi, Tomoki Ogoshi, and Akira Harada). SECTION 3 DETECTION METHODS IN CHEMOSENSING. 12 Fluorescent Detection Principles and Strategies (Raman Parkesh, Emma B. Veale, and Thorfinnur Gunnlaugsson). 13 New Fluorophore Design (Michael D. Heagy). 14 Colorimetric Sensor Design (Kevin L. Bicker, Sheryl L. Wiskur, and John J. Lavigne). 15 Electrochemical Detection (Simon R. Bayly, George Z. Chen, and Paul D. Beer). 16 Surface Plasmon Resonance and Quartz Crystal Microbalance Methods for Detection of Molecular Interactions (Yang Liu, Archana Jaiswal, Mark A. Poggi, and W. David Wilson). 17 Array-Based Sensors (Pavel Anzenbacher and Manuel A. Palacios). SECTION 4 CHEMOSENSORS: CASE STUDIES. 18 Design of Cation-Selective Synthetic Fluorescent Indicators (Christoph J. Fahrni). 19 Anion Sensors (Philip A. Gale and Claudia Caltagirone). 20 Chemosensors: Case Studies of Indicators for Organic Molecules (Oleksandr Rusin, Jorge O. Escobedo, and Robert M. Strongin). 21 Molecular Recognition Elements for Toxin and Pathogen Detection (Daniel M. Lewallen, Duane M. Hatch, and Suri S. Iyer). 22 Chemical Sensing and Detection in Forensic Science (Simon W. Lewis). Index.
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