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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Chemotherapy-induced acral erythema (also known as "palmar-plantar erythrodysesthesia" or "hand-foot syndrome") is reddening, swelling, numbness and desquamation on palms and soles that can occur after chemotherapy in patients with cancer. These skin changes usually are well demarcated. Acral erythema typically disappears within a few weeks after discontinuation of the offending drug. Synonyms for acral erythema (AE) include: hand-foot syndrome, palmar-plantar erythrodysesthesia, peculiar AE, chemotherapy-induced AE, toxic erythema of the palms and soles, palmar-plantar erythema, and Burgdorf s reaction.