HIV (Human Immunodeficiency Virus) infects cells of the immune system: Infection results in the progressive deterioration of the immune system, breaking down the body s ability to fend off some infections and other diseases. Combination antiretroviral therapy (ART) prevents the HIV virus from multiplying in the body: If the reproduction of the HIV virus stops, then the body s immune cells are able to live longer and provide the body with protection from infections.In this book we tried to introduce a new way of therapy for the treatment of HIV infection as most of the antiretroviral rugs contains complex molecule with complicated structure. Here we simplify the structure of chicoric acid, a natural molecule, into halfmer which also proved as an effective therapy.