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Sickle cell disease remains a major public health concern. The WHO estimates the carrier rate at 6.5%, which would suggest the existence of 30,000 cases of major forms of Thalassemia and Sickle Cell Disease in Morocco. Our study focuses on the epidemiological, clinical, genetic, therapeutic and evolutionary profile of sickle cell syndrome major in the hospital of Kénitra, Morocco. It is a retrospective and descriptive study over 5 years (2011-2015). 232 sickle cell children under 15 years of age, admitted for bacterial infections and vaso-occlusive crises to pediatric wards.The analysis enabled us to collect data from patients' medical records. The results show that (3.77%) of patients hospitalized at the SP-CHP in Kénitra. The mean age of our inpatients was 8.41 ± 4.02 years, whereas the mean age recorded during screening was 5.7 ± 3.12 years. The SS form predominated until the age of 5, with a reported frequency of 55.5%.