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This book provides readers with an understanding of chiral separations, and offers a handy guide for selecting the best separation method, saving considerable time and cost in product development. It also discusses chiral separations in the biotechnological and pharmaceutical industries, as well as for agriculture and food applications. Specific topics covered include high pressure liquid chromatography (HPLC), nuclear magnetic resonance (NMR), supercritical fluid chromatography (SFC), capillary electrophoresis (CE), computational studies, and enantiomer selection. This is an essential text for analytical and separations scientists in the biotechnological, pharmaceutical, agricultural, and food industries, as well as students.
Discusses chiral separations and offers guidance for selecting the optimum method for desired results Chiral separations represent the most intriguing and, by some measures, most difficultseparations of chemical compounds. This book provides researchers and students an under-standing of chiral separations and offers a convenient route to selecting the best separation method, saving considerable time and cost in product development. Considering chiral separations in the biotechnological and pharmaceutical industries, as well as for food applications, Dr. Ahuja provides insights into a broad range of topics. Opening with a broad overview of chiral separations, regulatory considerations in drug product development, and basic issues in method development, the book: * Covers a variety of modern methods such as gas chromatography, high performance liquid chromatography, supercritical fluid chromatography, and capillary electrophoresis * Deals with the impact of chirality on the biological activity of small and large molecules * Provides detailed information on useful chiral stationary phases (CSPs) for HPLC * Includes handy information on selection of an appropriate CSP, including mechanistic studies * Offers strategies for fast method development with HPLC, SFC, and CE * Discusses preparatory methods utilized in the pharmaceutical industry With in-depth discussions of the current state of the field as well as suggestions to assist future developments, Chiral Separation Methods for Pharmaceutical and Biotechnological Products is an essential text for laboratory investigators, managers, and regulators who are involved in chiral separations in the pharmaceutical industry, as well as students preparing for careers in these fields.
Discusses chiral separations and offers guidance for selecting the optimum method for desired results Chiral separations represent the most intriguing and, by some measures, most difficultseparations of chemical compounds. This book provides researchers and students an under-standing of chiral separations and offers a convenient route to selecting the best separation method, saving considerable time and cost in product development. Considering chiral separations in the biotechnological and pharmaceutical industries, as well as for food applications, Dr. Ahuja provides insights into a broad range of topics. Opening with a broad overview of chiral separations, regulatory considerations in drug product development, and basic issues in method development, the book: * Covers a variety of modern methods such as gas chromatography, high performance liquid chromatography, supercritical fluid chromatography, and capillary electrophoresis * Deals with the impact of chirality on the biological activity of small and large molecules * Provides detailed information on useful chiral stationary phases (CSPs) for HPLC * Includes handy information on selection of an appropriate CSP, including mechanistic studies * Offers strategies for fast method development with HPLC, SFC, and CE * Discusses preparatory methods utilized in the pharmaceutical industry With in-depth discussions of the current state of the field as well as suggestions to assist future developments, Chiral Separation Methods for Pharmaceutical and Biotechnological Products is an essential text for laboratory investigators, managers, and regulators who are involved in chiral separations in the pharmaceutical industry, as well as students preparing for careers in these fields.
"This is an essential text for analytical and separations scientists in the biotechnological, pharmaceutical, agricultural, and food industries, as well as students." (Laboratory Journal, 22 November 2010)
"All chapters are thorough and well written by leading experts in the particular fields. The book provides researchers and students in the field of pharmaceutical sciences with a thorough understanding of chiral separations and offers a convenient route to selecting best chiral separation method." (Anal Bioanal Chem, 2011)
"This is an essential text for analytical and separations scientists in the biotechnological, pharmaceutical, agricultural, and food industries, as well as students." (Laboratory Journal, 22 November 2010)
"This is an essential text for analytical and separations scientists in the biotechnological, pharmaceutical, agricultural, and food industries, as well as students." (Laboratory Journal, 22 November 2010)