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Cancers are the second most common disease after cardiovascular disorders for maximum deaths in the world. Anticancer chemotherapy has many oral complications out of which oral mucositis is distressing for the patient and negatively affects the quality of life. Chlorhexidine, as a mouthrinse and in other delivery forms, has been investigated intensely concerning its prophylactic and therapeutic efficacy in oral mucositis. This book gives the reader a comprehensive outline of the various properties and applications of chlorhexidine and its benefits in prevention and management of the various oral complications that arise during cancer chemotherapy.