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This book is deliberated for undergraduate, graduate level students and researchers of Organic chemistry provide them detailed study and knowledge regarded synthesis of chromenopyrano-fused pyrazole derivatives by Domino Knoevenagel-hetero-Diels-Alder (DKHDA) reaction and their biological evaluation.This book contains literature information of previous work done on pyrano[2,3-c]pyrazoles, a novel synthetic way using TBA-HS under solvent free condition which is a greener approach to synthesize it, spectral analysis using NMR, DQF-COSY and NOESY, and single crystal X-ray diffraction studies of all the synthesized compounds and their biological study to analyze their potency and application. I wish this book will work as a helpful future reference of DKHDA synthesis of chromenopyrano-fused pyrazole scaffolds and their biological applications for the students, researchers and chemists and assist them to set up new and more proficient route using DOMINO approach.