Chymotrypsin Inhibitors:N-substituted sulfamoylacetamides - Siddiqui, Sabahat Zahra;Shafique, Maryam
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A facile method has been implemented for the synthesis of different N-substituted sulfamoylacetamides (3a-q) by the reaction of 4-acetamidobenzenesulfonyl chloride with a series of different alkyl/aralkyl/aryl amines in aqueous alkaline media under dynamic control of pH at 9-10. The structures of the synthesized N-substituted sulfamoylacetamides were elucidated through spectral analysis like FT-IR, EIMS and 1H-NMR. The synthesized derivatives were further screened against Chymotrypsin enzyme. The results revealed that most of the synthesized compounds were found to be potent chymotrypsin inhibitor.…mehr

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Produktbeschreibung
A facile method has been implemented for the synthesis of different N-substituted sulfamoylacetamides (3a-q) by the reaction of 4-acetamidobenzenesulfonyl chloride with a series of different alkyl/aralkyl/aryl amines in aqueous alkaline media under dynamic control of pH at 9-10. The structures of the synthesized N-substituted sulfamoylacetamides were elucidated through spectral analysis like FT-IR, EIMS and 1H-NMR. The synthesized derivatives were further screened against Chymotrypsin enzyme. The results revealed that most of the synthesized compounds were found to be potent chymotrypsin inhibitor.
Autorenporträt
Sabahat Z. Siddiqui is a winner of Academic Roll of Honor and Certificates of Merit throughout her academic career in the field of Organic Chemistry. She authored 20 research publications. She worked as a visiting research scholar under the guidance of Prof. Gary A. Molander at University of Pennsylvania, USA under IRSIP scholarship (HEC-Pakistan).