This book provides the reader with a contemporary and comprehensive overview about the molecular, cellular and system-wide principles of circadian clock regulation. Emphasis is placed on the importance of circadian clocks for the timing of therapeutic interventions.
This book provides the reader with a contemporary and comprehensive overview about the molecular, cellular and system-wide principles of circadian clock regulation. Emphasis is placed on the importance of circadian clocks for the timing of therapeutic interventions.
Artikelnr. des Verlages: 86024268, 978-3-642-25949-4
2013
Seitenzahl: 428
Erscheinungstermin: 1. Mai 2013
Englisch
Abmessung: 241mm x 160mm x 29mm
Gewicht: 748g
ISBN-13: 9783642259494
ISBN-10: 3642259499
Artikelnr.: 34468688
Herstellerkennzeichnung
Books on Demand GmbH
In de Tarpen 42
22848 Norderstedt
info@bod.de
040 53433511
Inhaltsangabe
Part I. Molecular and cellular basis of circadian clocks. Molecular components of the mammalian circadian clock. The epigenetic language of circadian clocks. Peripheral circadian oscillators in mammals. Cellular mechanisms of circadian pacemaking: beyond transcriptional loops. The clock in the brain: Neurons, glia and networks in daily rhythms.- Part II. Circadian control of physiology and behavior. Circadian clocks and metabolism. The circadian control of sleep. Daily regulation of hormone profiles. Circadian clocks and mood-related behaviors. Part III. Chronopharmacology and chronotherapy. Molecular Clocks in Pharmacology. Cancer chronotherapeutics: Experimental, theoretical and clinical aspects. Pharmacological modulators of the circadian clock as potential therapeutic drugs: Focus on genotoxic/anticancer therapy. Light and the human circadian clock.- Part IV. Systems biology of circadian clocks. Mathematical modeling in chronobiology. Mammalian circadian clock: the roles of transcriptional repression and delay. Genome-wide analyses of circadian systems. Proteomic approaches in circadian biology.
Part I. Molecular and cellular basis of circadian clocks. Molecular components of the mammalian circadian clock. The epigenetic language of circadian clocks. Peripheral circadian oscillators in mammals. Cellular mechanisms of circadian pacemaking: beyond transcriptional loops. The clock in the brain: Neurons, glia and networks in daily rhythms.- Part II. Circadian control of physiology and behavior. Circadian clocks and metabolism. The circadian control of sleep. Daily regulation of hormone profiles. Circadian clocks and mood-related behaviors. Part III. Chronopharmacology and chronotherapy. Molecular Clocks in Pharmacology. Cancer chronotherapeutics: Experimental, theoretical and clinical aspects. Pharmacological modulators of the circadian clock as potential therapeutic drugs: Focus on genotoxic/anticancer therapy. Light and the human circadian clock.- Part IV. Systems biology of circadian clocks. Mathematical modeling in chronobiology. Mammalian circadian clock: the roles of transcriptional repression and delay. Genome-wide analyses of circadian systems. Proteomic approaches in circadian biology.
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