Daniel Barr

Clathrin-Independent Endocytosis of ErbB2 in Human Breast Cancer Cells

Peering Into the Mysteries of Clathrin-Independent Endocytosis

• Broschiertes Buch

Produktbeschreibung

Endocytosis is an essential cellular process required
for functions including nutrient uptake, membrane
recycling, and signal transduction. In comparison to
the clathrin-mediated pathway, clathrin-independent
pathways are poorly understood. New work is now
beginning to reveal a picture of multiple
non-clathrin pathways. Findings presented in this
book identify that ErbB2 is internalized through a
non-clathrin pathway in geldanamycin-treated SKBr3
human breast cancer cells. ErbB2 internalization
resembled a newly described non-clathrin pathwaytermed the GEEC pathway, a pathway thought to be
specific for internalization of GPI-anchored
proteins. Suprisingly, ErbB2 and GPI-anchored
proteins also co-localized with chimeric fusion
proteins containing transmembrane domains, proteins
expected to be excluded from the GEEC pathway.
Combined with other data from the lab, these results
suggest that this pathway is not specific for
GPI-anchored proteins and may instead represent a
bulk internalization pathway.

Produktdetails

• Verlag: VDM Verlag Dr. Müller
• Seitenzahl: 68
• Englisch
• Gewicht: 135g
• ISBN-13: 9783639150698
• ISBN-10: 3639150694
• Artikelnr.: 26328236

Autorenporträt

Daniel Barr completed his PhD in molecular and cellular biology
from the State University of New York at Stony Brook, and his
bachelors degree in anthropology from the University of New
Mexico. His graduate work focused on membrane biology and
endocytosis in mammalian cells. He lives in San Diego with his wife.