Clathrin-Independent Endocytosis of ErbB2 in Human Breast Cancer Cells
Peering Into the Mysteries of Clathrin-Independent Endocytosis
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Endocytosis is an essential cellular process requiredfor functions including nutrient uptake, membranerecycling, and signal transduction. In comparison tothe clathrin-mediated pathway, clathrin-independentpathways are poorly understood. New work is nowbeginning to reveal a picture of multiplenon-clathrin pathways. Findings presented in thisbook identify that ErbB2 is internalized through anon-clathrin pathway in geldanamycin-treated SKBr3human breast cancer cells. ErbB2 internalizationresembled a newly described non-clathrin pathwaytermed the GEEC pathway, a pathway thought to bespecific for i...
Endocytosis is an essential cellular process required
for functions including nutrient uptake, membrane
recycling, and signal transduction. In comparison to
the clathrin-mediated pathway, clathrin-independent
pathways are poorly understood. New work is now
beginning to reveal a picture of multiple
non-clathrin pathways. Findings presented in this
book identify that ErbB2 is internalized through a
non-clathrin pathway in geldanamycin-treated SKBr3
human breast cancer cells. ErbB2 internalization
resembled a newly described non-clathrin pathwaytermed the GEEC pathway, a pathway thought to be
specific for internalization of GPI-anchored
proteins. Suprisingly, ErbB2 and GPI-anchored
proteins also co-localized with chimeric fusion
proteins containing transmembrane domains, proteins
expected to be excluded from the GEEC pathway.
Combined with other data from the lab, these results
suggest that this pathway is not specific for
GPI-anchored proteins and may instead represent a
bulk internalization pathway.
for functions including nutrient uptake, membrane
recycling, and signal transduction. In comparison to
the clathrin-mediated pathway, clathrin-independent
pathways are poorly understood. New work is now
beginning to reveal a picture of multiple
non-clathrin pathways. Findings presented in this
book identify that ErbB2 is internalized through a
non-clathrin pathway in geldanamycin-treated SKBr3
human breast cancer cells. ErbB2 internalization
resembled a newly described non-clathrin pathwaytermed the GEEC pathway, a pathway thought to be
specific for internalization of GPI-anchored
proteins. Suprisingly, ErbB2 and GPI-anchored
proteins also co-localized with chimeric fusion
proteins containing transmembrane domains, proteins
expected to be excluded from the GEEC pathway.
Combined with other data from the lab, these results
suggest that this pathway is not specific for
GPI-anchored proteins and may instead represent a
bulk internalization pathway.
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