Click Chemistry and DNA Binders - Althagafi, Ismail
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This book provides an overview in recent progress in the field of synthesis and interactions of pi-conjugated DNA binders through Click chemistry. The synbook of alkyne- and azide substituted oligoheteroaromatic compounds, were designed to be used as building blocks for Click reactions. The Pd-catalysed cross-coupling of azide-substituted building blocks to form oligoheteroaromatics is also described. The characterisation of the new pi-conjugated molecules utilising Click chemistry between alkyne- and azide-substituted compounds leading to a series of structurally-varied di- and tricationic…mehr

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Produktbeschreibung
This book provides an overview in recent progress in the field of synthesis and interactions of pi-conjugated DNA binders through Click chemistry. The synbook of alkyne- and azide substituted oligoheteroaromatic compounds, were designed to be used as building blocks for Click reactions. The Pd-catalysed cross-coupling of azide-substituted building blocks to form oligoheteroaromatics is also described. The characterisation of the new pi-conjugated molecules utilising Click chemistry between alkyne- and azide-substituted compounds leading to a series of structurally-varied di- and tricationic oligoheteroaromatic putative DNA binders. The DNA-binding studies for the di- and tricationic oligoheteroaromatic compounds using a variety of biophysical techniques to quantify DNA binding and elucidate binding modes. Finally, the overall conclusions of the study, including future studies and applications are presented.
Autorenporträt
Ismail I. Althagafi, 1980Ph.D. in Chemistry, Cardiff University, Cardiff, UK, 2013.Assistant Professor, Department of Chemistry, University College in Al-Jamom, Umm Al-Qura University, Makkah, Saudi Arabia