Click Chemistry for Biotechnology and Materials Science

Herausgegeben von Lahann, Joerg

• Gebundenes Buch

Produktbeschreibung

Click Chemistry for Biotechnology and Materials Science examines the fundamentals of click chemistry, its application tothe precise design and synthesis of macromolecules, and itsnumerous applications in materials science and biotechnology. The book surveys the current research, discusses emerging trendsand future applications, and provides an important nucleation pointfor research. Edited by one of the top young innovators (accordingto Technology Review) and with contributions from pioneers in thefield, Click Chemistry for Biotechnology and MaterialsScience provides an ideal reference for anyone wanting to learnmore about click reactions.

Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 432
• Erscheinungstermin: 1. Dezember 2009
• Englisch
• Abmessung: 250mm x 175mm x 28mm
• Gewicht: 1068g
• ISBN-13: 9780470699706
• ISBN-10: 0470699701
• Artikelnr.: 27492602

Autorenporträt

Joerg Lahann is Dow Corning Assistant Professor in the Chemical Engineering Department at the University of Michigan (USA). He was educated at the University of Saarland (Germany) and obtained his PhD at RWTH Aachen (Germany) in Macromolecular Chemistry. From 1999 to 2001, Joerg Lahann was a postdoctoral associate in the Chemical Engineering Department of Massachusetts Institute of Technology (USA) and he then spent one year at Harvard University and Massachusetts Institute of Technology (HMST). He joined the Chemical Engineering Department at the University of Michigan in 2003. Professor Lahann has received a number of honors and awards including Technology Review TR100 Young Innovator Award, NSF CAREER Award, the Justus-Liebig Fellowship of the Fonds of the German Industry, Sigma XI - Full Membership, German Science Foundation Postdoctoral Grant, Borchers Prize of the RWTH Aachen (given to graduate students for an outstanding performance), and the Young Student Achievement Award of the Fonds of the German Industry. His research interests are broadly related to surface engineering as well as biomedical engineering and nanotechnology.

Inhaltsangabe

Preface. List of Contributors. Acknowledgments. 1 Click Chemistry: A
Universal Ligation Strategy for Biotechnology and Materials Science (Joerg
Lahann). 1.1 Introduction. 1.2 Selected Examples of Click Reactions in
Materials Science and Biotechnology. 1.3 Potential Limitations of Click
Chemistry. 1.4 Conclusions. References. 2 Common Synthons for Click
Chemistry in Biotechnology (Christine Schilling, Nicole Jung and Stefan
Bräse). 2.1 Introduction - Click Chemistry. 2.2 Peptides and Derivatives.
2.3 Peptoids. 2.4 Peptidic Dendrimers. 2.5 Oligonucleotides. 2.6
Carbohydrates. 2.7 Conclusion. References. 3 Copper-free Click Chemistry
(Jeremy M. Baskin and Carolyn R. Bertozzi). 3.1 Introduction. 3.2
Bio-orthogonal Ligations. 3.3 Applications of Copper-free Click
Chemistries. 3.4 Summary and Outlook. References. 4 Protein and Peptide
Conjugation to Polymers and Surfaces Using Oxime Chemistry (Heather D.
Maynard, Rebecca M. Broyer and Christopher M. Kolodziej). 4.1 Introduction.
4.2 Protein/Peptide-Polymer Conjugates. 4.3 Immobilization of Proteins and
Peptides on Surfaces. 4.4 Conclusions. References. 5 The Role of Click
Chemistry in Polymer Synthesis (Jean-Francois Lutz and Brent S. Sumerlin).
5.1 Introduction. 5.2 Polymerization via CuAAC. 5.3 Post-polymerization
Modification via Click Chemistry. 5.4 Polymer-Biomacromolecule Conjugation.
5.5 Functional Nanomaterials. 5.6 Summary and Outlook. References. 6
Blocks, Stars and Combs: Complex Macromolecular Architecture Polymers via
Click Chemistry (Sebastian Sinnwell, Andrew J. Inglis, Martina H. Stenzel
and Christopher Barner-Kowollik). 6.1 Introduction. 6.2 Block Copolymers.
6.3 Star Polymers. 6.4 Graft Copolymers. 6.5 Concluding Remarks.
References. 7 Click Chemistry on Supramolecular Materials (Wolfgang H.
Binder and Robert Sachsenhofer). 7.1 Introduction. 7.2 Click Reactions on
Rotaxanes, Cyclodextrines and Macrocycles. 7.3 Click Reactions on DNA. 7.4
Click Reactions on Supramolecular Polymers. 7.5 Click Reactions on
Membranes. 7.6 Click Reactions on Dendrimers. 7.7 Click Reactions on Gels
and Networks. 7.8 Click Reactions on Self-assembled Monolayers. References.
8 Dendrimer Synthesis and Functionalization by Click Chemistry for
Biomedical Applications (Daniel Q. McNerny, Douglas G. Mullen, Istvan J.
Majoros, Mark M. Banaszak Holl and James R. Baker Jr). 8.1 Introduction.
8.2 Dendrimer Synthesis. 8.3 Dendrimer Functionalization. 8.4 Conclusions
and Future Directions. References. 9 Reversible Diels-Alder Cycloaddition
for the Design of Multifunctional Network Polymers (Amy M. Peterson and
Giuseppe R. Palmese). 9.1 Introduction. 9.2 Design of Polymer Networks. 9.3
Application of Diels-Alder Linkages to Polymer Systems. 9.4 Conclusions.
References. 10 Click Chemistry in the Preparation of Biohybrid Materials
(Heather J. Kitto, Jan Lauko, Floris P. J. T. Rutjes and Alan E. Rowan).
10.1 Introduction. 10.2 Polymer-containing Biohybrid Materials. 10.3
Biohybrid Structures based on Protein Conjugates. 10.4 Biohybrid
Amphiphiles. 10.5 Glycoconjugates. 10.6 Conclusions. References. 11
Functional Nanomaterials using the Cu-catalyzed Huisgen Cycloaddition
Reaction (Sander S. van Berkel, Arnold W.G. Nijhuis, Dennis W.P.M. Löwik
and Jan C.M. van Hest). 11.1 Introduction. 11.2 Inorganic Nanoparticles.
11.3 Carbon-based Nanomaterials. 11.4 Self-assembled Organic Structures.
11.5 Virus Particles. 11.6 Conclusions. References. 12 Copper-catalyzed
'Click' Chemistry for Surface Engineering (Himabindu Nandivada and Joerg
Lahann). 12.1 Introduction. 12.2 Synthesis of Alkyne or
Azide-functionalized Surfaces. 12.3 Spatially Controlled Click Chemistry.
12.4 Copper-catalyzed Click Chemistry for Bioimmobilization. 12.5 Summary.
References. 13 Click Chemistry in Protein Engineering, Design, Detection
and Profiling (Daniela C. Dieterich and A. James Link). 13.1 Introduction.
13.2 Posttranslational Functionalization of Proteins with Azides and
Alkynes. 13.3 Cotranslational Functionalization of Proteins with Azides and
Alkynes. 13.4 BONCAT: Identification of Newly Synthesized Proteins via
Noncanonical Amino Acid Tagging. 13.5 Conclusions and Future Prospects.
References. 14 Fluorogenic Copper(I)-catalyzed Azide-Alkyne Cycloaddition
Reactions Reactions and their Applications in Bioconjugation (Céline Le
Droumaguet and Qian Wang). 14.1 Click Reaction for Bioconjugation
Applications. 14.2 Significance of Fluorogenic Reactions in Bioconjugation.
14.3 CuAAC-based Fluorogenic Reaction. 14.4 Applications of CuAAC in
Bioconjugation. 14.5 Conclusions. References. 15 Synthesis and
Functionalization of Biomolecules via Click Chemistry (Christine Schilling,
Nicole Jung and Stefan Bräse). 15.1 Introduction. 15.2 Labeling of
Macromolecular Biomolecules. 15.3 Syntheses of Natural Products and
Derivatives. 15.4 Enzymes and Click Chemistry. 15.5 Synthesis of
Glycosylated Molecular Architectures. 15.6 Synthesis of Nitrogen-rich
Compounds: Polyazides and Triazoles. 15.7 Conclusions. References. 16
Unprecedented Electro-optic Properties in Polymers and Dendrimers Enabled
by Click Chemistry Based on the Diels-Alder Reactions (Jingdong Luo,
Tae-Dong Kim and Alex K.-Y. Jen). 16.1 Introduction. 16.2 Diels-Alder Click
Chemistry for Highly Efficient Side-chain E-O Polymers. 16.3 Diels-Alder
Click Chemistry for Crosslinkable E-O Polymers Containing Binary NLO
Chromophores. 16.4 Diels-Alder Click Chemistry for NLO Dendrimers. 16.5
Conclusions. References. Index.