Climate change related mitochondrial conflict syndrome is a symbiotic dysfunction in the archaeal derived neanderthalic and neoneanderthalic cell with the mitochondria in conflict with the rest of the symbiotic cellular organelle leading to systemic disorders like psychiatric disorders, malignant neoplasms, neurodegeneration, metabolic syndrome X, emerging viral infections and autoimmune disease. The human cell regresses evolutionarily to a primitive anaerobic neanderthalic or neoneanderthalic phenotype. This mitochondrial conflict with the rest of the symbiotic cellular organelle forms the basis of human civilization disease. This can be called as a mitochondrial conflict disorder where the mitochondria is in conflict with the archaeal derived cell and its symbiotic organelle content. Thus global warming leads to regressive cellular evolution to an anaerobic phenotype. The homo sapien phenotype with less of archaeal endosymbiosis were the cellular symbiotic elements are in harmony becomes exitinct consequent to global warming related archaeal endosymbiosis.