Clinical and Statistical Considerations in Personalized Medicine

Herausgeber: Carini, Claudio; Chang, Mark; Menon, Sandeep M

• Gebundenes Buch

Produktbeschreibung

Despite the vast amount of literature on biomarkers, there is no comprehensive book that integrates the clinical and statistical components. This book is one of the first to incorporate both the clinical and statistical aspects of biomarkers in the personalized medicine paradigm. Leading clinicians, biostatisticians, regulators, commercial professionals, and researchers address the opportunities and challenges in successfully applying biomarkers in drug discovery and preclinical and clinical development. They cover a wide spectrum of personalized medicine-related topics, including epigenetics, adaptive designs, statistical methods, regulatory issues, and more.

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Produktdetails

• Verlag: Taylor & Francis Ltd (Sales)
• Seitenzahl: 376
• Erscheinungstermin: 27. März 2014
• Englisch
• Abmessung: 236mm x 157mm x 23mm
• Gewicht: 658g
• ISBN-13: 9781466593862
• ISBN-10: 1466593865
• Artikelnr.: 39616158

Autorenporträt

Claudio Carini, Sandeep Menon, Mark Chang

Inhaltsangabe

Biomarkers for Drug Development: The Time Is Now! RNAi Screens: Triumphs
and Tribulations. Current Advances in Epigenetics. Biomarkers and Precision
Medicine: The Case of Rare Diseases. Biomarker-Informed Adaptive Design.
Fitting the Dose: Adaptive Staggered Dose Design. Evidence-Based Adaptive
Statistical Decision and Design Strategies for Maximizing the Efficiency of
Clinical Oncology Development Programs with Predictive Biomarkers.
Biomarker Identification in Clinical Trials. Multiplicity in
Pharmacogenomics. Patient-Reported Outcomes in Personalized Medicine.
Regulatory Issues in Use of Biomarkers in Drug Development. Index.