With a better understanding of the cellular mechanisms of neurotoxin and the advances in botulinum biotechnology, future botulinum neurotoxin products are likely to be even more effective and customized to the specific indications and tailored to the needs of patients. BoNT is a strong therapeutic instrument, but it must be used correctly. Increasing its implementation, under various circumstances, makes it the most versatile drug on the market, spanning almost all medical specialties. Although deemed efficient and secure, there are still many constraints, such as injection-related discomfort, comparatively brief length of reaction, the chance of immunogenicity, and high.