M. Wick / W. Pinggera / P. Lehmann

Clinical Aspects and Laboratory. Iron Metabolism, Anemias

Novel concepts in the anemias of malignancies and renal and rheumatoid diseases

• Broschiertes Buch

Produktbeschreibung

Disturbances of iron metabolism, particularly iron deficiency, are among the most commonly overlooked or misinterpreted diseases. This is due to the fact that the determination of transport iron in serum or plasma, which used to be the test in conventional diagnosis, does not allow a representative estimate of the body's total iron reserves. A proper estimate was formerly possible only by the costly and invasive determination of storage iron in the bone marrow, however, sensitive, well-standardized immuno-chemical methods for the precise determination of the iron storage protein ferritin in plasma are now available. Since the secretion of this protein correctly reflects the iron stores in the majority of cases, these methods permit fast and reliable diagnosis, particularly of iron deficiency conditions.
This book is intended to contribute to a better understanding of the main pathophysiological foundations and diagnostic principles.

Table of contents:
Introduction.- Iron Metabolism.- Erythropoiesis.- Disturbances of Iron Metabolism / Disturbances of Erythropoiesis and Hemolysis.- Diagnosis of Disturbances of Iron Metabolism / Disturbances of Erythropoiesis.- Iron Deficiency - Diagnosis and Therapy.- Disturbances of Iron Distribution - Diagnosis and Therapy.- Disturbances of Iron Utilization - Diagnosis and Therapy.- Iron Overload.- Non-iron-induced Disturbances of Erythropoiesis.- Methods of Determination in Serum/Plasma and Blood.- References.- Subject Index

Produktdetails

• Verlag: Springer Austria
• 5th edition
• Englisch
• ISBN-13: 9783211006955
• ISBN-10: 3211006958
• Artikelnr.: 06672443

Inhaltsangabe

- Introduction
- Physiological Principles of Iron Metabolism and Erythropoiesis Absorption of Iron
- Iron Transport
- Iron Storage
- Iron Distribution
- Iron Requirement
- Iron Losses
- Erythropoiesis
- Erythrocyte Degradation;Disturbances of Iron Metabolism/Disturbances of Erythropoiesis and Hemolysis Disturbances of the Body's Iron Balance
- Iron Deficiency
- Iron Overload
- Disturbances of Iron Distribution
- Disturbances of Iron Utilization
- Non-iron-induced Disturbances of Erythropoiesis
- Pathologically Increased Hemolysis;Diagnosis of disturbances of Iron Metabolism Disturbances of Erythropoiesis The Body's Iron Balance
- Iron Deficiency and Decreased Ferritin Concentrations
- Iron Overload - Elevated Ferritin Concentrations
- Disturbances of Iron Distribution
- Disturbances of Iron Utilization
- Non-iron-induced Disturbances of Erythropoiesis;Therapie of Anemias Therapy of Iron Deficiency
- Therapy of Iron Distribution Disorders
- Therapy of Iron Utilization Disorders
- Deficiencies in the Cofactors of Erythropoiesis
- Autologous Blood Donors
- Other Indications;Methods The Blood Count
- Hemoglobin (Hb)
- Hematokrit (Het)
- Erythrocytes
- Reticulocytes
- Tests for the Diagnosis of Disorders of Iron Metabolism
- Determination of Iron
- Determination of Iron-Binding Proteins: Immunoassay Methods
- Ferritin
- Transferrin (Tf)
- Transferrin Receptor (fR)
- Haptoglobin
- Ceruloplasmin (Cp)
- Determination of Vitamin B12 and Folic Acid
- Erythropoietin (EPO)
- Tests for the Diagnosis of Chronic Inflammation (ACD)
- Erythrocyte Sedimentation Rate (ESR)
- C-Reactive Protein (CRP)
- Rheimatoid Factors (RF)
- Iron/Copper Relation and Ceoruloplasmin;ReferencesRecommended ReadingSubject Index.