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We have previously described our extensive experiences with clinical genetic and dysmorphology in a plethora of publications. In a previous study, we reported 43 children with uncommon, rare and very rare genetic and hereditary disorders whom were observed during three-year period (2016-2018). In that series , very rare genetic, the case number 104 of Sanjad-Sakati-Richardson-Kirk syndrome in the world, the case number 130 of Townes Brocks syndrome, and the case number 170 of Coffin Siris syndrome in the world. The aim of this paper is to describe our 2019 extraordinary new experiences with genetic disorders and dysmorphic syndromes.