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This issue of Heart Failure Clinics, guest edited by Dr. Francesco Antonini-Canterin, is dedicated to Clinical Heart Failure Scenarios: from Prevention to Overt Disease and Rehabilitation. This issue is one of four selected each year by series consulting editor Dr. Eduardo Bossone. This issue aims to provide a comprehensive overview over the broad spectrum of clinical scenarios of heart failure, starting from prevention in asymptomatic phase to acute and chronic congestive heart failure to modern rehabilitation.