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This book constitutes the proceedings of the 11th Workshop on Clinical Image-Based Procedures, CLIP 2022, which was held in conjunction with MICCAI 2022, in Singapore in September 2022. The 9 full papers included in this book were carefully reviewed and selected from 12 submissions. They focus on the applicability of basic research methods in the clinical practice by creating holistic patient models as an important step towards personalized healthcare.