This is a historical document of the origin and progress of clinical medicine research at the AUB School of Medicine from 1920?1974 and a synopsis of the founding of the Syrian Protestant College by Presbyterian missionaries. Later on the college became known the American University of Beirut in Beirut, Lebanon (1920). Throughout the manuscript, the author attempts to comment on certain important clinical research as well as his journey into clinical research both in Lebanon and in the United States. An interesting section of the book includes the discovery of the pulmonary circulation by Ibn an-Nafis.