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Clinical Trials in Neurology comprehensively tackles the methodology and design of clinical trials in neurological disease. A general section deals with the ethical aspects, drug development and regulatory requirements, basic trial designs and the statistics used. A diseases section tackles specific aspects of disorders, focusing on the relevant ethical issues, outcome variables and experience with large multicentre trials.
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Clinical Trials in Neurology comprehensively tackles the methodology and design of clinical trials in neurological disease. A general section deals with the ethical aspects, drug development and regulatory requirements, basic trial designs and the statistics used. A diseases section tackles specific aspects of disorders, focusing on the relevant ethical issues, outcome variables and experience with large multicentre trials.
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Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Produktdetails
- Produktdetails
- Verlag: Springer / Springer London / Springer, Berlin
- Artikelnr. des Verlages: 978-1-85233-239-6
- 2001 edition
- Seitenzahl: 542
- Erscheinungstermin: 5. Mai 2001
- Englisch
- Abmessung: 265mm x 186mm x 38mm
- Gewicht: 1192g
- ISBN-13: 9781852332396
- ISBN-10: 1852332395
- Artikelnr.: 09769438
- Verlag: Springer / Springer London / Springer, Berlin
- Artikelnr. des Verlages: 978-1-85233-239-6
- 2001 edition
- Seitenzahl: 542
- Erscheinungstermin: 5. Mai 2001
- Englisch
- Abmessung: 265mm x 186mm x 38mm
- Gewicht: 1192g
- ISBN-13: 9781852332396
- ISBN-10: 1852332395
- Artikelnr.: 09769438
1 Ethical Considerations.- 2 Assessment Measures and Clinical Scales.- 3 Ethics, Outcome Variables and Clinical Scales: The Clinician's Point of View.- 4 The Cochrane Collaboration Reviews in Neurology.- 5 Drug Development Stages.- 6 Drug Regulatory Requirements in the United Kingdom and Europe.- 7 Drug Regulatory Requirements in the United States.- 8 Quality Control and Data Monitoring: A Guide To Good Clinical Practice.- 9 Statistical Issues in Clinical Trials in Neurology.- 10 Analysis of Results: Statistical Principles.- 11 Survival Analysis.- 12 The Intention-to-Treat Principle for Clinical Trials.- 13 Statistical Analysis of Repeated-Measures Data with Drop-outs.- 14 The Role of Meta-analyses in Clinical Research: Uses and Limitations.- 15 Outcome Variables in Dementia Trials: Conceptual and Practical Issues.- 16 Dementia: Trial Design and Experience with Large Multicentre Trials.- 17 Cerebrovascular Disease: Basic Designs, Sample Sizes and Pitfalls.- 18 Clinical Trials in Stroke Prevention in North America.- 19 Cerebrovascular Disease: Experience Within Large Multicentre Trials.- 20 Epilepsy: Ethics, Outcome Variables and Clinical Scales.- 21 Epilepsy: Basic Designs, Sample Sizes and Experience with Large Multicentre Trials.- 22 Headache: Ethics, Outcome Variables and Clinical Studies.- 23 Headache: Basic Trial Designs, Sample Sizes and Pitfalls.- 24 Headache: Experience with Large Multicenter Trials in the Treatment of Migraine Attacks.- 25 Parkinson's Disease: Outcome Variables and Clinical Scales.- 26 Parkinson's Disease: A Review of Drug Trials.- 27 Parkinson's Disease: Experience with Large Multicentre Trials.- 28 Tremor: Clinical Measurement of Impairment, Disability and Handicap.- 29 Tremor: Natural Behaviour, Trial Design and Physiological OutcomeMeasures.- 30 Multiple Sclerosis: Ethics, Outcome Variables and Clinical Scales.- 31 Multiple Sclerosis: Study Design, Sample Sizes and Pitfalls.- 32 Multiple Sclerosis: Experience with Large Clinical Trials.- 33 Motor Neurone Disease: Ethics, Outcome Variables and Clinical Scales.- 34 Motor Neurone Disease: Basic Designs, Sample Sizes and Pitfalls.- 35 Motor Neurone Disease: Experience with Large Multicentre Trials.- 36 Peripheral Neuropathies: Controlled Clinical Trials.- 37 Peripheral Neuropathies: Experience with Large Multicentre Trials.- 38 Disorders of the Neuromuscular Junction: Outcome Measures and Clinical Scales.- 39 Myasthenia Gravis: Basic Designs, Sample Sizes and Pitfalls.- 40 Myopathies: Ethics, Outcome Variables and Clinical Scales.- 41 Myopathies: Basic Designs, Sample Sizes and Pitfalls.
1 Ethical Considerations.- 2 Assessment Measures and Clinical Scales.- 3 Ethics, Outcome Variables and Clinical Scales: The Clinician's Point of View.- 4 The Cochrane Collaboration Reviews in Neurology.- 5 Drug Development Stages.- 6 Drug Regulatory Requirements in the United Kingdom and Europe.- 7 Drug Regulatory Requirements in the United States.- 8 Quality Control and Data Monitoring: A Guide To Good Clinical Practice.- 9 Statistical Issues in Clinical Trials in Neurology.- 10 Analysis of Results: Statistical Principles.- 11 Survival Analysis.- 12 The Intention-to-Treat Principle for Clinical Trials.- 13 Statistical Analysis of Repeated-Measures Data with Drop-outs.- 14 The Role of Meta-analyses in Clinical Research: Uses and Limitations.- 15 Outcome Variables in Dementia Trials: Conceptual and Practical Issues.- 16 Dementia: Trial Design and Experience with Large Multicentre Trials.- 17 Cerebrovascular Disease: Basic Designs, Sample Sizes and Pitfalls.- 18 Clinical Trials in Stroke Prevention in North America.- 19 Cerebrovascular Disease: Experience Within Large Multicentre Trials.- 20 Epilepsy: Ethics, Outcome Variables and Clinical Scales.- 21 Epilepsy: Basic Designs, Sample Sizes and Experience with Large Multicentre Trials.- 22 Headache: Ethics, Outcome Variables and Clinical Studies.- 23 Headache: Basic Trial Designs, Sample Sizes and Pitfalls.- 24 Headache: Experience with Large Multicenter Trials in the Treatment of Migraine Attacks.- 25 Parkinson's Disease: Outcome Variables and Clinical Scales.- 26 Parkinson's Disease: A Review of Drug Trials.- 27 Parkinson's Disease: Experience with Large Multicentre Trials.- 28 Tremor: Clinical Measurement of Impairment, Disability and Handicap.- 29 Tremor: Natural Behaviour, Trial Design and Physiological OutcomeMeasures.- 30 Multiple Sclerosis: Ethics, Outcome Variables and Clinical Scales.- 31 Multiple Sclerosis: Study Design, Sample Sizes and Pitfalls.- 32 Multiple Sclerosis: Experience with Large Clinical Trials.- 33 Motor Neurone Disease: Ethics, Outcome Variables and Clinical Scales.- 34 Motor Neurone Disease: Basic Designs, Sample Sizes and Pitfalls.- 35 Motor Neurone Disease: Experience with Large Multicentre Trials.- 36 Peripheral Neuropathies: Controlled Clinical Trials.- 37 Peripheral Neuropathies: Experience with Large Multicentre Trials.- 38 Disorders of the Neuromuscular Junction: Outcome Measures and Clinical Scales.- 39 Myasthenia Gravis: Basic Designs, Sample Sizes and Pitfalls.- 40 Myopathies: Ethics, Outcome Variables and Clinical Scales.- 41 Myopathies: Basic Designs, Sample Sizes and Pitfalls.