Salmonella is one the pathogens which is known to cause a wide array of diseases throughout the globe especially Enteric fever (Typhoid).It is an important interest of the research fraternity to decipher the actual mechanism of Salmonella pathogenesis and to develop suitable therapeutics as well as vaccines for the disease.The book briefs about the molecular mechanisms of Salmonella pathogenesis. This book report deals with the methodology to effectively clone and express Salmonella pathogenecity Island (SPI)genes into a suitable host.