Thomas E. Ouldridge

Coarse-Grained Modelling of DNA and DNA Self-Assembly

• Gebundenes Buch

Produktbeschreibung

This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.

Produktdetails

• Springer Theses
• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 86097813, 978-3-642-30516-0
• 2012
• Seitenzahl: 188
• Erscheinungstermin: 7. Juli 2012
• Englisch
• Abmessung: 241mm x 160mm x 15mm
• Gewicht: 430g
• ISBN-13: 9783642305160
• ISBN-10: 3642305164
• Artikelnr.: 35543641

Inhaltsangabe

A Novel DNA Model.- Methods.- Finite Size Effects.- Stuctural and Mechanical Properties of Model DNA.- Thermodynamic Properties of Model DNA.- Modelling DNA Tweezers.- Modelling a DNA Walker.

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A Novel DNA Model.- Methods.- Finite Size Effects.- Structural and Mechanical Properties of Model DNA.- Thermodynamic Properties of Model DNA.- Modelling DNA Tweezers.- Modelling a DNA Walker.