Renilde Loeckx

Cold War Triangle

How Scientists in East and West Tamed HIV

• Broschiertes Buch

Produktbeschreibung

The extraordinary story of scientists in East and West combatting HIV A small group of scientists were doggedly working in the field of antiviral treatments when the AIDS epidemic struck. Faced with one of the grand challenges of modern biology of the twentieth century, scientists worked across the political divide of the Cold War to produce a new class of antivirals. Their molecules were developed by a Californian start-up together with teams of scientists at the Rega Institute of KU Leuven and the Institute of Organic Chemistry and Biochemistry (IOCB) of the Academy of Sciences in Prague. These molecules became the cornerstone of the blockbuster drugs now used to combat and prevent HIV. Cold War Triangle gives an insight into the human face of science as it recounts the extraordinary story of scientists in East and West who overcame ideological barriers and worked together for the benefit of humanity.

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Produktdetails

• Verlag: Leuven University Press
• Seitenzahl: 192
• Erscheinungstermin: 15. November 2017
• Englisch
• Abmessung: 234mm x 159mm x 12mm
• Gewicht: 311g
• ISBN-13: 9789462701137
• ISBN-10: 946270113X
• Artikelnr.: 49362111

Autorenporträt

Renilde Loeckx is former Ambassador of Belgium.

Inhaltsangabe

Foreword Acknowledgements
Introduction A brief excursion into the history of virology and vaccines
Chapter I. Leuven: a hotbed for antiviral research The cross-fertilization
between academia and pharma Vaccines and celebrity scientists
Chapter II. Behind the Iron Curtain The molecular revolution goes east The
Academy of Sciences in Prague
Chapter III. Strange bedfellows: a Czech chemist and a Flemish virologist
Auspicious omens A young prodigy's path to science
Chapter IV. The sixties in Leuven and Prague Antiviral penicillin Spring
turns into winter
Chapter V. Enzymes: the secret of life as chemistry At Stanford, a new
world opens up The Rega Institute cuts corporate ties and goes its own way
Chapter VI. From interferon to nucleosides A first encounter with
nucleosides A fateful meeting in Göttingen Bringing compounds to life
Chapter VII. Breaking away from interferon A molecule for all seasons
Cloning the interferon gene
Chapter VIII. The first antiviral drugs NA TO supports a nucleosides
network Bringing antiviral therapy to the clinic
Chapter IX. Aids emerges in the shadow of the Cold War The East German
connection The Cold War heats up Revealing a retrovirus
Chapter X. From passivity to action A pivotal year A triangular
collaboration is set in motion Launching an aids laboratory in Leuven: the
story of d4T
Chapter XI. First attempts to halt the epidemic Two irons in the fire:
Bristol-Myers and Janssen Taking stock after AZT Holý's compound is active
against HIV
Chapter XII. Finding the best therapy: the one-a-day-pill A new start-up:
Gilead Sciences The birth of Cidofovir, Tenofovir and Adefovir
Epilogue: Of scientists and crusaders
Album Notes References Index