John M. Garland

Colony-Stimulating Factors

Molecular & Cellular Biology, Second Edition,

• Broschiertes Buch

Produktbeschreibung

Concentrating on proven data and adopting a structure-function approach, this text provides grounding for an intricate understanding of the molecular biology, physiological mechanisms, and routine clinical use in disease settings of colony-stimulating factors (CSFs). This edition includes eight additional chapters, with updates of recently-discovered and established CSFs, each indexed individually.

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Produktdetails

• Verlag: CRC Press
• 2. Auflage
• Seitenzahl: 580
• Erscheinungstermin: 10. Oktober 2019
• Englisch
• Abmessung: 254mm x 178mm x 31mm
• Gewicht: 1076g
• ISBN-13: 9780367400958
• ISBN-10: 0367400952
• Artikelnr.: 58057226

Autorenporträt

John M. Garland\,

Inhaltsangabe

Overview: introduction to the haematopoietic system
surrogate assays for haematopoietic stem cell activity
receptors for haematopoietic regulators
regulation of the cell cycle by kinases and cyclins
gene organization and regulation
cytokines and apoptosis - the mechanism of regulation of cell death
haematopoietic microenvironments
extracellular matrix- and membrane-bound cytokines
transfection of stem cells and gene therapy. Colony-stimulating factor: granulocyte-macrophage colony-stimulating factor and its receptor
granulocyte colony-stimulating factor
human interleukin-3 - an overview
macrophage colony-stimulating factor
erythropoietic
the role of interleukin-4 in normal and malignant human haematopoietic effects of interleukin-1
kit-ligand-stem cell factor
interleukin-5. Cytokines: macrophages inflammatory protein-1 alpha
transforming growth factor-beta, tumour necrosis factor-alpha, and macrophage inflammatory protein-1 alpha are bidirectional regulators of haematopoietic cell growth
leukaemia inhibitory factor
interleukin-12 in haematopoiesis
ex vivo expansion of haematopoietic stem and progenitor cells
clinical use of cytokines.