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This book aims to publish a study which targeted to investigate the cytotoxic effects of Rosmarinic acid alone and in combination with Cisplatin on HepG2 cell line and to investigate the possible chemotherapeutic effects of Rosmarinic acid. Also, the possible protective effect of Rosmarinic acid against Cisplatin-induced nephrotoxicity in mice through the assessment of oxidative stress, inflammatory, apoptotic markers in the kidney.