Combination Therapies

Biological Response Modifiers in the Treatment of Cancer and Infectious Diseases
Herausgegeben:Garaci, E.; Goldstein, Allan L.

• Broschiertes Buch

Produktbeschreibung

Over the past decade many of the key lymphokines, hormones and growth factors that help regulate the immune system have been defined. These molecules, termed biological response modifiers (BRMs) , have been sequenced, synthesized and produced in large enough quantities to test in animals and humans resulting in the development of new approaches to the treatment of human disease, in particular, cancers and infectious diseases. Advances in this area have also led to rethinking therapies against a range of autoimmune disorders and other diseases associated with immune and endocrine imbalances. BRMs currently are being applied clinically as both primary and adjunctive therapy to enhance the effectiveness of traditional treatments by maximizing their activities and to protect critical tissues against intolerable chemotherapeutic and radiation damage. Present constraints against the use of BRMs revolve around the nature of these substances in vivo, where many of their actions and the majority of their interactions and synergies remain to be elucidated. For example, as these molecules are thought to exert their effects locally, the systemic administration of lymphokines, cytokines and growth factors at doses adequate to produce a wanted anti-tumor effect in many instances is intolerably toxic. Efforts to overcome this formidable problem have led scientists to begin to explore the transfer of genes known to encode for these molecules into cells which otherwise inadequately elicit or produce anti-tumor or anti-infective responses.

Produktdetails

• Verlag: Springer / Springer US / Springer, Berlin
• Artikelnr. des Verlages: 978-1-4613-6472-6
• Softcover reprint of the original 1st ed. 1992
• Seitenzahl: 332
• Erscheinungstermin: 21. Oktober 2012
• Englisch
• Abmessung: 254mm x 178mm x 19mm
• Gewicht: 627g
• ISBN-13: 9781461364726
• ISBN-10: 1461364728
• Artikelnr.: 39506579

Inhaltsangabe

I - Combination Immunotherapy: Molecular, Cellular, and Gene Approaches.- Combination Therapy With Thymic Hormones and Cytokines After Chemotherapy in Cancer Treatment.- Immune Therapy of Human Cancers.- Use of IL-2 and Lymphocytes Following Bone Marrow Transplantation.- Combo: New Concepts and Methods for Designing and Analyzing Experiments on Combination Therapy.- Combinations of Lymphocyte Activating Agents for Expansion of Tumor Infiltrating Lymphocytes from Renal Cell Carcinoma.- II - Clinical Applications of Combination Chemoimmunotherapy in Cancer.- IL-2 Based Combination Therapy of Malignant Disease: Summary of the Phase I Experience at the Cleveland Clinic.- The Role of Combination Biologic Therapy in the Immunotherapeutic Approach to the Treatment of Renal Cell Carcinoma.- Maintenance Treatment With Recombinant Interferon Alfa-2b Prolongs Remission and Survival in Patients With Multiple Myeloma Responding to Induction Chemotherapy.- Combination of Fluorouracil and Interferon: Mechanisms of Interaction and Clinical Studies.- Combination Chemotherapy and Cytokines in the Treatment of Advanced Primary Lung Cancer: Controlled Clinical Trial Three Year Results.- Tumor Immunotherapy With Combined Interleukins Injected Perilymphatically: Experimental and Clinical Findings.- III - Combination Approaches and Gene Therapy in the Treatment of Aids and Other Infectious Diseases.- Combination Therapies With Cytokines and Anti-Cytokines in Murine Opportunistic Infections.- Treatment and Pharmacokinetics of Liposomal-Amphotericin B Patients With Systemic Fungal Infections.- The Potential Role of Immunomodulation in the Treatment of HIV-Infection and Malignant Diseases.- Use of Drugs Targeted To Inhibit Different Stages of the HIV Life Cycle in the Treatment of AIDS.- AspirinAs a Biological Response Modifier.- Biological Therapies in Geriatric Populations.- Thymosin: An Innovative Approach to the Treatment of Chronic Hepatitis B.- Cell Wall Constituents of Candida Albicans As Biological Response Modifiers.- Cytokines Modulate HIV Replication and the Activity of Antiviral Drugs in Cells of Monocyte/Macrophage Lineage.- IV - Mechanism of Action and Synergy between Drugs, Biological Response Modifiers, and/or Vaccines in Combination Therapies.- The Case for Synergy of Thymic Hormones and Interleukins in Immune Reconstitution.- Inducing Immunity to Human Melanoma Cells: Opening the Bag of Immunological Tricks.- Immune Mediated Tumor Destruction: Challenges for the 1990's.- Abnormal Immunoregulation in Human Cancer at the Actual Tumor Site.- The Immunobiology of Human Fc? Receptors.- Synergy between G-CSF and WR-2721: Effects on Enhancing Hemopoietic Reconstitution and Increasing Survival Following Exposure to Ionizing Radiation.- ST 789, A Candidate for Combination Therapies of Infections and Cancer.- QS-21 Augments the Antibody Response to a Synthetic Peptide Vaccine Compared to Alum.- Synergistic Regulation of LAK Lymphocyte Cytotoxicity by Combination Cytokine and Cisplatin Treatment.- The Biological Response Modifiers Interleukin-2 and Tumor Necrosis Factor-a Modulate the Cytotoxic Activity of Tumor Infiltrating Lymphocytes Against Human Colon Cancer Cells.- Isolation and Chemical Characterization of a Novel Thymic Hormone That Synergizes With GRF and TRH in Enhancing Release of Growth Hormone and Prolactin.- V - Prospects and Future Directions Using Animal Models to Define Effective Combination Therapies with Biological Response Modifiers.- Cytokine-Based Combined Modality Approaches to the Treatment of Murine Renal Cancer.- Rationalefor Therapeutic Approaches with Thymosin ? 1, Interleukin 2 and Interferon in Combination with Chemotherapy.- Mechanisms of Combined IL-l/IL-2 and IL-l/IFN Therapy in Mice Injected with Metastatic Tumor Cells.- Cancer Immunotherapy: Preclinical Studies With Triazene Compounds.